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@article{1726960, author = {Treml, Jakub and Leláková, Veronika and Šmejkal, Karel and Paulickova, T and Labuda, S and Granica, S and Havlik, J and Jankovská, Dagmar and Padrtová, Tereza and Hosek, J}, article_location = {BASEL}, article_number = {9}, doi = {http://dx.doi.org/10.3390/biom9090468}, keywords = {stilbenoid; antioxidant; pro-oxidant; pyocyanin; Nrf2; macrophages}, language = {eng}, issn = {0066-605X}, journal = {Biomolecules}, title = {Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System}, volume = {9}, year = {2019} }
TY - JOUR ID - 1726960 AU - Treml, Jakub - Leláková, Veronika - Šmejkal, Karel - Paulickova, T - Labuda, S - Granica, S - Havlik, J - Jankovská, Dagmar - Padrtová, Tereza - Hosek, J PY - 2019 TI - Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System JF - Biomolecules VL - 9 IS - 9 PB - MDPI SN - 0066605X KW - stilbenoid KW - antioxidant KW - pro-oxidant KW - pyocyanin KW - Nrf2 KW - macrophages N2 - The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture. Piceatannol (4) had shown reactive oxygen species (ROS) scavenging activity, whereas isorhapontigenin (18) had a mild direct antioxidant effect and activated Nrf2-antioxidant response element (ARE) system and elevated expression of Nrf2 and catalase. Their effects shown on cells in vitro warrant their further study in vivo. ER -
TREML, Jakub, Veronika LELÁKOVÁ, Karel ŠMEJKAL, T PAULICKOVA, S LABUDA, S GRANICA, J HAVLIK, Dagmar JANKOVSKÁ, Tereza PADRTOVÁ and J HOSEK. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. \textit{Biomolecules}. BASEL: MDPI, 2019, vol.~9, No~9, 16 pp. ISSN~0066-605X. Available from: https://dx.doi.org/10.3390/biom9090468.
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