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@article{1726978,
author = {Vítovec, Jiří and Špinar, Jindřich and Špinarová, Lenka},
article_number = {1},
keywords = {Canagliflozin; Cardiovascular and renal safety; Programme CANVAS; Type 2 diabetes mellitus},
language = {cze},
issn = {1212-4540},
journal = {Kardiologická revue},
title = {CANVAS – Canagliflozin a kardiovaskulární a renální vliv u diabetes mellitus 2. Typu},
url = {https://www.kardiologickarevue.cz/casopisy/kardiologicka-revue/2019-1-12/canvas-canagliflozin-a-kardiovaskularni-a-renalni-vliv-u-diabetes-mellitus-2-typu-109103},
volume = {21},
year = {2019}
}
TY - JOUR
ID - 1726978
AU - Vítovec, Jiří - Špinar, Jindřich - Špinarová, Lenka
PY - 2019
TI - CANVAS – Canagliflozin a kardiovaskulární a renální vliv u diabetes mellitus 2. Typu
JF - Kardiologická revue
VL - 21
IS - 1
SP - 15 - 18
EP - 15 - 18
PB - Ambit Media a.s.
SN - 12124540
KW - Canagliflozin
KW - Cardiovascular and renal safety
KW - Programme CANVAS
KW - Type 2 diabetes mellitus
UR - https://www.kardiologickarevue.cz/casopisy/kardiologicka-revue/2019-1-12/canvas-canagliflozin-a-kardiovaskularni-a-renalni-vliv-u-diabetes-mellitus-2-typu-109103
N2 - Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that reduces glycaemia as well as blood pressure, body weight, and albuminuria in people with diabetes. The CANVAS Programme integrated data from two trials involving a total of 10,142 participants with type 2 diabetes and high cardiovascular risk. Participants in each trial were randomly assigned to receive canagliflozin or placebo and were followed for a mean of 188.2 weeks. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. Conclusions: In two trials involving patients with type 2 diabetes and an elevated risk of cardiovascular disease, patients treated with canagliflozin had a significantly lower risk of cardiovascular events than those who received placebo. A boundary higher risk of amputation, primarily at the level of the toe or metatarsus was observed in the study. These complications, however, were not proved in subsequent observational databases. © 2019, Ambit Media a.s.. All rights reserved.
ER -
VÍTOVEC, Jiří, Jindřich ŠPINAR a Lenka ŠPINAROVÁ. CANVAS – Canagliflozin~a~kardiovaskulární~a~renální vliv u~diabetes~mellitus~2. Typu. \textit{Kardiologická revue}. Ambit Media a.s., 2019, roč.~21, č.~1, s.~15 - 18. ISSN~1212-4540.
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