| VARINSKA, L., L. FABER, M. KELLO, E. PETROVOVA, L. BALAZOVA, P. SOLAR, M. COMA, P. URDZIK, J. MOJZIS, Emil ŠVAJDLENKA, P. MUCAJI a P. GAL. -Escin Effectively Modulates HUVECs Proliferation and Tube Formation. Molecules. BASEL: Mayer und Muller, 2018, roč. 23, č. 1, 15 s. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules23010197. |
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@article{1727081,
author = {Varinska, L. and Faber, L. and Kello, M. and Petrovova, E. and Balazova, L. and Solar, P. and Coma, M. and Urdzik, P. and Mojzis, J. and Švajdlenka, Emil and Mucaji, P. and Gal, P.},
article_location = {BASEL},
article_number = {1},
doi = {http://dx.doi.org/10.3390/molecules23010197},
keywords = {-escin; HUVECs; angiogenesis; bFGF; CAM},
language = {eng},
issn = {1420-3049},
journal = {Molecules},
title = {-Escin Effectively Modulates HUVECs Proliferation and Tube Formation},
volume = {23},
year = {2018}
}
TY - JOUR
ID - 1727081
AU - Varinska, L. - Faber, L. - Kello, M. - Petrovova, E. - Balazova, L. - Solar, P. - Coma, M. - Urdzik, P. - Mojzis, J. - Švajdlenka, Emil - Mucaji, P. - Gal, P.
PY - 2018
TI - -Escin Effectively Modulates HUVECs Proliferation and Tube Formation
JF - Molecules
VL - 23
IS - 1
PB - Mayer und Muller
SN - 14203049
KW - -escin
KW - HUVECs
KW - angiogenesis
KW - bFGF
KW - CAM
N2 - In the present study we evaluated the anti-angiogenic activities of -escin (the major active compound of Aesculus hippocastanum L. seeds). Human umbilical-vein endothelial cells (HUVECs) were used as an in vitro model for studying the molecular mechanism underlying the anti-angiogenic effect of -escin. We investigated the in vitro effects on proliferation, migration, and tube formation of HUVECs and in vivo anti-angiogenic activity was evaluated in a chick chorioallantoic membrane (CAM) angiogenesis assay. Moreover, the effect on gene expressions was determined by the RT2 ProfilerTM human angiogenesis PCR Array. It was found that -escin exerts inhibitory effect on the basic fibroblast growth factor (bFGF)-induced proliferation, migration and tube formation, as well as CAM angiogenesis in vivo. The inhibition of critical steps of angiogenic process observed with -escin could be partially explained by suppression of Akt activation in response to bFGF. Moreover, the anti-angiogenic effects of -escin could also be mediated via inhibition of EFNB2 and FGF-1 gene expressions in endothelial cells. In conclusion, -escin affects endothelial cells as a negative mediator of angiogenesis in vitro and in vivo and may therefore be considered as a promising candidate for further research elucidating its underlying mechanism of action.
ER -
VARINSKA, L., L. FABER, M. KELLO, E. PETROVOVA, L. BALAZOVA, P. SOLAR, M. COMA, P. URDZIK, J. MOJZIS, Emil ŠVAJDLENKA, P. MUCAJI a P. GAL. -Escin Effectively Modulates HUVECs Proliferation and Tube Formation. \textit{Molecules}. BASEL: Mayer und Muller, 2018, roč.~23, č.~1, 15 s. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules23010197.
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