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@article{1727151,
author = {Kovac, I. and Durkac, J. and Holly, M. and Jakubcova, K. and Perzelova, V. and Mucaji, P. and Švajdlenka, Emil and Sabol, F. and Legath, J. and Belak, J. and Smetana, K. and Gal, P.},
article_location = {HOBOKEN},
article_number = {1},
doi = {http://dx.doi.org/10.1111/jphp.12316},
keywords = {excisional wound; incisional wound; phytotherapy; rat; tissue repair and regeneration},
language = {eng},
issn = {0022-3573},
journal = {JOURNAL OF PHARMACY AND PHARMACOLOGY},
title = {Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds},
volume = {67},
year = {2015}
}
TY - JOUR
ID - 1727151
AU - Kovac, I. - Durkac, J. - Holly, M. - Jakubcova, K. - Perzelova, V. - Mucaji, P. - Švajdlenka, Emil - Sabol, F. - Legath, J. - Belak, J. - Smetana, K. - Gal, P.
PY - 2015
TI - Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds
JF - JOURNAL OF PHARMACY AND PHARMACOLOGY
VL - 67
IS - 1
SP - 117-125
EP - 117-125
PB - WILEY-BLACKWELL
SN - 00223573
KW - excisional wound
KW - incisional wound
KW - phytotherapy
KW - rat
KW - tissue repair and regeneration
N2 - Objectives Although the exact underlying mechanisms are still unknown, Plantago lanceolata L. (PL) water extracts are frequently used to stimulate wound healing and to drain abscesses. Therefore, in this experimental study the effect of PL water extract on skin wound healing was studied in Sprague-Dawley rats. Methods Two excisional and one incisional skin wounds were performed on the back of each rat. Wounds were treated for three consecutive days with two different concentrations of the aqueous extract of PL. Rats were sacrificed 7, 14, and 21 days after surgery. Samples of wounds were processed for macroscopic (excisions wound contraction measurement), biomechanical (incisions - wound tensile strength (TS) measurement) and histological examination (excisions). Key findings It was shown that open wounds treated with PL extract contained myofibroblasts and demonstrated significantly higher contraction rates. Furthermore, significantly increased wound TSs were recorded in treated rats as a consequence of increased organization of extracellular matrix proteins, such as the collagen type 1. Conclusions We demonstrated that PL aqueous extract improves skin wound healing in rats. However, further research need to be performed to find optimal therapeutic concentration, and exact underlying mechanism prior obtained results may be introduced into the clinical practice.
ER -
KOVAC, I., J. DURKAC, M. HOLLY, K. JAKUBCOVA, V. PERZELOVA, P. MUCAJI, Emil ŠVAJDLENKA, F. SABOL, J. LEGATH, J. BELAK, K. SMETANA a P. GAL. Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds. \textit{JOURNAL OF PHARMACY AND PHARMACOLOGY}. HOBOKEN: WILEY-BLACKWELL, 2015, roč.~67, č.~1, s.~117-125. ISSN~0022-3573. Dostupné z: https://dx.doi.org/10.1111/jphp.12316.
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