ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT a Marek MALÍK. Heart Rate Dependency and Inter-Lead Variability of the T Peak - T End Intervals. Frontiers in Physiology. Lausanne: Frontiers Media, 2020, roč. 11, DEC 2020, s. 1-19. ISSN 1664-042X. Dostupné z: https://dx.doi.org/10.3389/fphys.2020.595815.
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Základní údaje
Originální název Heart Rate Dependency and Inter-Lead Variability of the T Peak - T End Intervals
Autoři ANDRŠOVÁ, Irena (203 Česká republika, domácí), Katerina HNATKOVA (203 Česká republika), Martina ŠIŠÁKOVÁ (203 Česká republika, domácí), Ondřej TOMAN (203 Česká republika, domácí), Peter SMETANA (40 Rakousko), Katharina M. HUSTER (40 Rakousko), Petra BARTHEL (276 Německo), Tomáš NOVOTNÝ (203 Česká republika, domácí), Georg SCHMIDT (276 Německo) a Marek MALÍK (203 Česká republika, garant).
Vydání Frontiers in Physiology, Lausanne, Frontiers Media, 2020, 1664-042X.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30105 Physiology
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 4.566
Kód RIV RIV/00216224:14110/20:00117726
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.3389/fphys.2020.595815
UT WoS 000603040500001
Klíčová slova anglicky T wave peak; T wave spatial loop; heart rate dependency; ECG lead comparison; sex differences
Štítky 14110211, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 13. 1. 2021 09:43.
Anotace
The electrocardiographic (ECG) assessment of the T peak-T end (Tpe) intervals has been used in many clinical studies, but several related physiological aspects have not been reported. Specifically, the sources of the Tpe differences between different ECG leads have not been systematically researched, the relationship of Tpe duration to underlying heart rate has not been firmly established, and little is known about the mutual correspondence of Tpe intervals measured in different ECG leads. This study evaluated 796,620 10-s 12-lead ECGs obtained from long-term Holters recorded in 639 healthy subjects (311 female) aged 33.8 +/- 9.4 years. For each ECG, transformation to orthogonal XYZ lead was used to measure Tpe in the orthogonal vector magnitude (used as a reference for lead-to-lead comparisons) and to construct a three-dimensional T wave loop. The loop roundness was expressed by a ratio between its circumference and length. These ratios were significantly related to the standard deviation of Tpe durations in different ECG leads. At the underlying heart rate of 60 beats per minute, Tpe intervals were shorter in female than in male individuals (82.5 +/- 5.6 vs 90.0 +/- 6.5 ms, p < 0.0001). When studying linear slopes between Tpe intervals measured in different leads and the underlying heart rate, we found only minimal heart rate dependency, which was not systematic across the ECG leads and/or across the population. For any ECG lead, positive Tpe/RR slope was found in some subjects (e.g., 79 and 25% of subjects for V2 and V4 measurements, respectively) and a negative Tpe/RR slope in other subjects (e.g., 40 and 65% for V6 and V5, respectively). The steepest positive and negative Tpe/RR slopes were found for measurements in lead V2 and V4, respectively. In all leads, the Tpe/RR slope values were close to zero, indicating, on average, Tpe changes well below 2 ms for RR interval changes of 100 ms. On average, longest Tpe intervals were measured in lead V2, the shortest in lead III. The study concludes that the Tpe intervals measured in different leads cannot be combined. Irrespective of the measured ECG lead, the Tpe interval is not systematically heart rate dependent, and no heart rate correction should be used in clinical Tpe investigations.
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