Anti-inflammatory and antioxidant properties of chemical
constituents of Broussonetia papyrifera

J 2020

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC et. al.

Základní údaje

Originální název

Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera

Autoři

MALANÍK, Milan (203 Česká republika, garant, domácí), Jakub TREML (203 Česká republika, domácí), Veronika LELÁKOVÁ (703 Slovensko, domácí), Daniela NYKODÝMOVÁ (203 Česká republika, domácí), Michal ORAVEC (203 Česká republika), Jaromír MAREK (203 Česká republika, domácí) a Karel ŠMEJKAL (203 Česká republika, domácí)

Vydání

Bioorganic Chemistry, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, 0045-2068

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.275

Kód RIV

RIV/00216224:14160/20:00117745

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1016/j.bioorg.2020.104298

UT WoS

000592397400007

Klíčová slova anglicky

Broussonetia papyrifera; Anti-inflammatory; Antioxidant; NF-kappa B

Štítky

CF SAXS, rivok, ÚMF, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 10. 2024 15:00, Ing. Marie Švancarová

Anotace

V originále

Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.

Návaznosti

90127, velká výzkumná infrastruktura

Název: CIISB II

Citovat

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK a Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. Bioorganic Chemistry. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, roč. 104, NOV, s. 104298-104304. ISSN 0045-2068. Dostupné z: https://dx.doi.org/10.1016/j.bioorg.2020.104298.

@article{1727696,
   author = {Malaník, Milan and Treml, Jakub and Leláková, Veronika and Nykodýmová, Daniela and Oravec, Michal and Marek, Jaromír and Šmejkal, Karel},
   article_location = {SAN DIEGO},
   article_number = {NOV},
   doi = {http://dx.doi.org/10.1016/j.bioorg.2020.104298},
   keywords = {Broussonetia papyrifera; Anti-inflammatory; Antioxidant; NF-kappa B},
   language = {eng},
   issn = {0045-2068},
   journal = {Bioorganic Chemistry},
   title = {Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera},
   url = {https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub},
   volume = {104},
   year = {2020}
}

TY  - JOUR
ID  - 1727696
AU  - Malaník, Milan - Treml, Jakub - Leláková, Veronika - Nykodýmová, Daniela - Oravec, Michal - Marek, Jaromír - Šmejkal, Karel
PY  - 2020
TI  - Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
JF  - Bioorganic Chemistry
VL  - 104
IS  - NOV
SP  - 104298
EP  - 104298
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00452068
KW  - Broussonetia papyrifera
KW  - Anti-inflammatory
KW  - Antioxidant
KW  - NF-kappa B
UR  - https://www.sciencedirect.com/science/article/pii/S0045206820315960?via%3Dihub
N2  - Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-kappa B/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1 beta and TNF-alpha in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
ER  -

MALANÍK, Milan, Jakub TREML, Veronika LELÁKOVÁ, Daniela NYKODÝMOVÁ, Michal ORAVEC, Jaromír MAREK a Karel ŠMEJKAL. Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera. \textit{Bioorganic Chemistry}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, roč.~104, NOV, s.~104298-104304. ISSN~0045-2068. Dostupné z: https://dx.doi.org/10.1016/j.bioorg.2020.104298.

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