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@article{1730496,
author = {Jurj, A. and PopandBica, C. and Slabý, Ondřej and Stefan, C. D. and Cho, W. C. and Korban, S. S. and BerindanandNeagoe, I.},
article_location = {Basel},
article_number = {20},
doi = {http://dx.doi.org/10.3390/ijms21207688},
keywords = {extracellular vesicles; cancer; therapeutic agents; cell-to-cell communication},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer},
url = {https://www.mdpi.com/1422-0067/21/20/7688},
volume = {21},
year = {2020}
}
TY - JOUR
ID - 1730496
AU - Jurj, A. - Pop-Bica, C. - Slabý, Ondřej - Stefan, C. D. - Cho, W. C. - Korban, S. S. - Berindan-Neagoe, I.
PY - 2020
TI - Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer
JF - International Journal of Molecular Sciences
VL - 21
IS - 20
SP - 1-27
EP - 1-27
PB - Multidisciplinary Digital Publishing Institute
SN - 14220067
KW - extracellular vesicles
KW - cancer
KW - therapeutic agents
KW - cell-to-cell communication
UR - https://www.mdpi.com/1422-0067/21/20/7688
L2 - https://www.mdpi.com/1422-0067/21/20/7688
N2 - Communications among cells can be achieved either via direct interactions or via secretion of soluble factors. The emergence of extracellular vesicles (EVs) as entities that play key roles in cell-to-cell communication offer opportunities in exploring their features for use in therapeutics; i.e., management and treatment of various pathologies, such as those used for cancer. The potential use of EVs as therapeutic agents is attributed not only for their cell membrane-bound components, but also for their cargos, mostly bioactive molecules, wherein the former regulate interactions with a recipient cell while the latter trigger cellular functions/molecular mechanisms of a recipient cell. In this article, we highlight the involvement of EVs in hallmarks of a cancer cell, particularly focusing on those molecular processes that are influenced by EV cargos. Moreover, we explored the roles of RNA species and proteins carried by EVs in eliciting drug resistance phenotypes. Interestingly, engineered EVs have been investigated and proposed as therapeutic agents in various in vivo and in vitro studies, as well as in several clinical trials.
ER -
JURJ, A., C. POP-BICA, Ondřej SLABÝ, C. D. STEFAN, W. C. CHO, S. S. KORBAN and I. BERINDAN-NEAGOE. Tiny Actors in the Big Cellular World: Extracellular Vesicles Playing Critical Roles in Cancer. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, vol.~21, No~20, p.~1-27. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms21207688.
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