J 2020

Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis

IURCA, I., A. TIRPE, A. A. ZIMTA, C. MOLDOVAN, D. GULEI et. al.

Základní údaje

Originální název

Macrophages Interaction and MicroRNA Interplay in the Modulation of Cancer Development and Metastasis

Autoři

IURCA, I. (642 Rumunsko), A. TIRPE (642 Rumunsko), A. A. ZIMTA (642 Rumunsko), C. MOLDOVAN (642 Rumunsko), D. GULEI (642 Rumunsko), Ondřej SLABÝ (203 Česká republika, domácí), G. CONDORELLI (380 Itálie) a I. BERINDAN-NEAGOE (642 Rumunsko, garant)

Vydání

Frontiers in Immunology, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-3224

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 7.561

Kód RIV

RIV/00216224:14110/20:00117883

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000537072800001

Klíčová slova anglicky

macrophage; cancer; metastasis; microRNA; invasion

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 17. 3. 2021 13:14, Mgr. Tereza Miškechová

Anotace

V originále

Advancement in cancer research has shown that the tumor microenvironment plays a crucial role in the installation, progression, and dissemination of cancer cells. Among the heterogeneous panel of cells within the malignant microenvironment are tumor-associated macrophages that are sustaining the malignant cells through strict feedback mechanisms and spatial distribution. Considering that the presence of metastasis is one of the main feature associated with decreased survival rates among patients, in the present article we briefly present the involvement of tumor-associated macrophages in the hallmarks of metastasis and their microRNA-related regulation with a focus on lung cancer in order to coordinate the vast information under one pathology. As shown, these cells have emerged as coordinators of immunosuppression, angiogenesis and lymphangiogenesis, vessel intravasation and extravasation of cancer cells, and premetastatic niche formation, transforming the macrophages in potential therapeutic targets and also prognostic markers according to their density within the tumor and polarization phenotype. An indirect therapeutic approach on tumor-associated macrophages can be also represented by regulation of microRNAs involved in their polarization and implicit oncogenic features. Examples of these microRNAs consist in the highly studied miR-21 and miR-155, but also other microRNA with less feedback in the literature: miR-1207-5p, miR-193b, miR-320a, and others.