MURTAZA, Babar, Aziz HICHAMI, Amira S. KHAN, Jiří PLESNÍK, Omar ŠERÝ, Alexander DIETRICH, Lutz BIRNBAUMER a Naim Akhtar KHAN. Implication of TRPC3 channel in gustatory perception of dietary lipids. Acta Physiologica. Hoboken: Wiley, 2021, roč. 231, č. 2, s. 1-15. ISSN 1748-1708. Dostupné z: https://dx.doi.org/10.1111/apha.13554. |
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@article{1732136, author = {Murtaza, Babar and Hichami, Aziz and Khan, Amira S. and Plesník, Jiří and Šerý, Omar and Dietrich, Alexander and Birnbaumer, Lutz and Khan, Naim Akhtar}, article_location = {Hoboken}, article_number = {2}, doi = {http://dx.doi.org/10.1111/apha.13554}, keywords = {Ca(2+)signalling; fat taste; fatty acids; lipids; TRPC3 channels}, language = {eng}, issn = {1748-1708}, journal = {Acta Physiologica}, title = {Implication of TRPC3 channel in gustatory perception of dietary lipids}, url = {https://doi.org/10.1111/apha.13554}, volume = {231}, year = {2021} }
TY - JOUR ID - 1732136 AU - Murtaza, Babar - Hichami, Aziz - Khan, Amira S. - Plesník, Jiří - Šerý, Omar - Dietrich, Alexander - Birnbaumer, Lutz - Khan, Naim Akhtar PY - 2021 TI - Implication of TRPC3 channel in gustatory perception of dietary lipids JF - Acta Physiologica VL - 231 IS - 2 SP - 1-15 EP - 1-15 PB - Wiley SN - 17481708 KW - Ca(2+)signalling KW - fat taste KW - fatty acids KW - lipids KW - TRPC3 channels UR - https://doi.org/10.1111/apha.13554 L2 - https://doi.org/10.1111/apha.13554 N2 - The pathogenesis of obesity has been associated with high intake of dietary fat, and some recent studies have explored the cellular mechanisms of oro-sensory detection of dietary fatty acids. We further assessed the role of transient receptor potential canonical (TRPC) channels in oro-sensory perception of dietary lipids. We determined by RT-qPCR and western blotting the expression of TRPC3/6/7 channels in mouse fungiform taste bud cells (mTBC). Immunocytochemistry was used to explore whether TRPC3 channels were co-expressed with fatty acid receptors. We employed wild-type (WT) mTBC, and those transfected with small interfering RNAs (siRNAs) against TRPC3 or STIM1. Ca(2+)signalling was studied in TBC fromTRPC3(-/-)mice and their WT littermates. We demonstrate that mouse fungiform taste bud cells (mTBC) express TRPC3, but not TRPC6 or TRPC7 channels, and their inactivation by siRNA or experiments on TBC fromTRPC3(-/-)mice brought about a decrease in fatty acid-induced gustatory Ca(2+)signalling, coupled with taste bud CD36 lipid sensor. TRPC3 channel activation was found to be under the control of STIM1 in lingual mTBC. Behavioural studies showed that spontaneous preference for a dietary long-chain fatty acid was abolished inTRPC3(-/-)mice, and in mice wherein lingual TRPC3 expression was silenced by employing siRNA. We report that lingual TRPC3 channels are critically involved in fat taste perception. ER -
MURTAZA, Babar, Aziz HICHAMI, Amira S. KHAN, Jiří PLESNÍK, Omar ŠERÝ, Alexander DIETRICH, Lutz BIRNBAUMER a Naim Akhtar KHAN. Implication of TRPC3 channel in gustatory perception of dietary lipids. \textit{Acta Physiologica}. Hoboken: Wiley, 2021, roč.~231, č.~2, s.~1-15. ISSN~1748-1708. Dostupné z: https://dx.doi.org/10.1111/apha.13554.
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