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@article{1732814,
author = {Leischner Fialová, Jindřiška and Raudenská, Martina and Jakubek, Milan and Kejik, Zdenek and Martásek, Pavel and Babula, Petr and Matkowski, Adam and Filipensky, Petr and Masařík, Michal},
article_location = {SHARJAH},
article_number = {7},
doi = {http://dx.doi.org/10.2174/1389557520666201118153242},
keywords = {Mitochondria; targeting; metabolism; cancer; treatment; inhibitors; hexokinase; tricarboxylic acid cycle; respiratory chain; electron transport chain},
language = {eng},
issn = {1389-5575},
journal = {Mini-reviews in medicinal chemistry},
title = {Novel Mitochondria-targeted Drugs for Cancer Therapy},
url = {https://www.eurekaselect.com/188152/article},
volume = {21},
year = {2021}
}
TY - JOUR
ID - 1732814
AU - Leischner Fialová, Jindřiška - Raudenská, Martina - Jakubek, Milan - Kejik, Zdenek - Martásek, Pavel - Babula, Petr - Matkowski, Adam - Filipensky, Petr - Masařík, Michal
PY - 2021
TI - Novel Mitochondria-targeted Drugs for Cancer Therapy
JF - Mini-reviews in medicinal chemistry
VL - 21
IS - 7
SP - 816-832
EP - 816-832
PB - BENTHAM SCIENCE PUBL LTD
SN - 13895575
KW - Mitochondria
KW - targeting
KW - metabolism
KW - cancer
KW - treatment
KW - inhibitors
KW - hexokinase
KW - tricarboxylic acid cycle
KW - respiratory chain
KW - electron transport chain
UR - https://www.eurekaselect.com/188152/article
N2 - The search for mitochondria-targeted drugs has dramatically risen over the last decade. Mitochondria are essential organelles serving not only as a powerhouse of the cell but also as a key player in cell proliferation and cell death. Their central role in the energetic metabolism, calcium homeostasis and apoptosis makes them an intriguing field of interest for cancer pharmacology. In cancer cells, many mitochondrial signaling and metabolic pathways are altered. These changes contribute to cancer development and progression. Due to changes in mitochondrial metabolism and changes in membrane potential, cancer cells are more susceptible to mitochondria-targeted therapy. The loss of functional mitochondria leads to the arrest of cancer progression and/or a cancer cell death. Identification of mitochondrial changes specific for tumor growth and progression, rational development of new mitochondria-targeted drugs and research on delivery agents led to the advance of this promising area. This review will highlight the current findings in mitochondrial biology, which are important for cancer initiation, progression and resistance, and discuss approaches of cancer pharmacology with a special focus on the anti-cancer drugs referred to as ‘mitocans’.
ER -
LEISCHNER FIALOVÁ, Jindřiška, Martina RAUDENSKÁ, Milan JAKUBEK, Zdenek KEJIK, Pavel MARTÁSEK, Petr BABULA, Adam MATKOWSKI, Petr FILIPENSKY and Michal MASAŘÍK. Novel Mitochondria-targeted Drugs for Cancer Therapy. \textit{Mini-reviews in medicinal chemistry}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2021, vol.~21, No~7, p.~816-832. ISSN~1389-5575. Available from: https://dx.doi.org/10.2174/1389557520666201118153242.
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