Intestinal Microbiota and Perspectives of the Use of
Meta-Analysis for Comparison of Ulcerative Colitis Studies

J 2021

Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies

KUSHKEVYCH, Ivan, Kristýna MARTÍNKOVÁ, Monika VÍTĚZOVÁ a Simon K.-M. R. RITTMANN

Základní údaje

Originální název

Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies

Autoři

KUSHKEVYCH, Ivan (804 Ukrajina, garant, domácí), Kristýna MARTÍNKOVÁ (203 Česká republika, domácí), Monika VÍTĚZOVÁ (203 Česká republika, domácí) a Simon K.-M. R. RITTMANN

Vydání

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10606 Microbiology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.964

Kód RIV

RIV/00216224:14310/21:00121032

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/jcm10030462

UT WoS

000615323900001

Klíčová slova anglicky

intestinal microbiome; sulfate-reducing bacteria; hydrogen sulfide; inflammatory bowel diseases; ulcerative colitis; meta-analysis

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 4. 2022 18:46, Mgr. Marie Šípková, DiS.

Anotace

V originále

Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.

Návaznosti

MUNI/A/1425/2020, interní kód MU

Název: Podpora výzkumné činnosti studentů Mikrobiologie

Investor: Masarykova univerzita, Podpora výzkumné činnosti studentů Mikrobiologie

Citovat

KUSHKEVYCH, Ivan, Kristýna MARTÍNKOVÁ, Monika VÍTĚZOVÁ a Simon K.-M. R. RITTMANN. Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies. Journal of Clinical Medicine. Basel: MDPI, 2021, roč. 10, č. 3, s. 1-21. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm10030462.

@article{1734417,
   author = {Kushkevych, Ivan and Martínková, Kristýna and Vítězová, Monika and Rittmann, Simon K.andM. R.},
   article_location = {Basel},
   article_number = {3},
   doi = {http://dx.doi.org/10.3390/jcm10030462},
   keywords = {intestinal microbiome; sulfate-reducing bacteria; hydrogen sulfide; inflammatory bowel diseases; ulcerative colitis; meta-analysis},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies},
   url = {https://doi.org/10.3390/jcm10030462},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1734417
AU  - Kushkevych, Ivan - Martínková, Kristýna - Vítězová, Monika - Rittmann, Simon K.-M. R.
PY  - 2021
TI  - Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies
JF  - Journal of Clinical Medicine
VL  - 10
IS  - 3
SP  - 1-21
EP  - 1-21
PB  - MDPI
SN  - 20770383
KW  - intestinal microbiome
KW  - sulfate-reducing bacteria
KW  - hydrogen sulfide
KW  - inflammatory bowel diseases
KW  - ulcerative colitis
KW  - meta-analysis
UR  - https://doi.org/10.3390/jcm10030462
L2  - https://doi.org/10.3390/jcm10030462
N2  - Meta-analysis is a statistical process summarizing comparable data from a number of scientific papers. The use of meta-analysis in microbiology allows decision-making that has an impact on public health policy. It can happen that the primary researches come to different conclusions, although these are targeted with the same research question. It is, therefore, inevitable to have the means to systematically evaluate information and compare research results. Ulcerative colitis together with Crohn’s disease are among the two main inflammatory bowel diseases. This chronic disease of the gastrointestinal tract, with an as yet unclear etiology, is presented by an uncontrolled inflammatory immune response in genetically predisposed individuals to as yet undefined environmental factors in interaction with the intestinal microbiota itself. In patients with ulcerative colitis (UC), changes in the composition and relative abundance of microorganisms could be observed. Sulfate-reducing bacteria (SRB), which commonly occur in the large intestine as part of the commensal microbiota of animals and humans involved in the pathogenesis of the disease, have been shown to occur. SRB are anaerobic organisms affecting short-chain fatty acid metabolism. This work outlines the perspectives of the use of meta-analysis for UC and changes in the representation of intestinal organisms in these patients.
ER  -

KUSHKEVYCH, Ivan, Kristýna MARTÍNKOVÁ, Monika VÍTĚZOVÁ a Simon K.-M. R. RITTMANN. Intestinal Microbiota and Perspectives of the Use of Meta-Analysis for Comparison of Ulcerative Colitis Studies. \textit{Journal of Clinical Medicine}. Basel: MDPI, 2021, roč.~10, č.~3, s.~1-21. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm10030462.

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