| AHMAD, Parwez, Marek SLÁVIK, Karolína TRACHTOVÁ, Natalia Anna GABŁO, Tomáš KAZDA, Dominik GURÍN, Pavel SMILEK, Zuzana HORÁKOVÁ, Břetislav GÁL, Markéta HERMANOVÁ, Pavel ŠLAMPA, Jiří ŠÁNA and Ondřej SLABÝ. Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients. CELLULAR ONCOLOGY. DORDRECHT: SPRINGER, 2020, vol. 43, No 3, p. 505-511. ISSN 2211-3428. Available from: https://dx.doi.org/10.1007/s13402-020-00507-7. |
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@article{1734956,
author = {Ahmad, Parwez and Slávik, Marek and Trachtová, Karolína and Gabło, Natalia Anna and Kazda, Tomáš and Gurín, Dominik and Smilek, Pavel and Horáková, Zuzana and Gál, Břetislav and Hermanová, Markéta and Šlampa, Pavel and Šána, Jiří and Slabý, Ondřej},
article_location = {DORDRECHT},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s13402-020-00507-7},
keywords = {Head and neck cancer; microRNAs; salivary microRNAs; Radiotherapy; IMRT},
language = {eng},
issn = {2211-3428},
journal = {CELLULAR ONCOLOGY},
title = {Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients},
url = {https://link.springer.com/article/10.1007/s13402-020-00507-7},
volume = {43},
year = {2020}
}
TY - JOUR
ID - 1734956
AU - Ahmad, Parwez - Slávik, Marek - Trachtová, Karolína - Gabło, Natalia Anna - Kazda, Tomáš - Gurín, Dominik - Smilek, Pavel - Horáková, Zuzana - Gál, Břetislav - Hermanová, Markéta - Šlampa, Pavel - Šána, Jiří - Slabý, Ondřej
PY - 2020
TI - Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients
JF - CELLULAR ONCOLOGY
VL - 43
IS - 3
SP - 505-511
EP - 505-511
PB - SPRINGER
SN - 22113428
KW - Head and neck cancer
KW - microRNAs
KW - salivary microRNAs
KW - Radiotherapy
KW - IMRT
UR - https://link.springer.com/article/10.1007/s13402-020-00507-7
L2 - https://link.springer.com/article/10.1007/s13402-020-00507-7
N2 - Purpose Progress in radiation therapy of head and neck squamous cell carcinomas (HNSCCs) is logically linked to the development of molecular predictors that would help to enhance individually tailored treatment. MicroRNA (miRNA) expression profiles in tumors have repeatedly been tested to optimize the molecular diagnostics of HNSCC. In addition to tumor tissues, miRNAs are stably present in body fluids, including saliva, and can thus be collected non-invasively. The aim of our current study was to evaluate whether salivary miRNAs have potential as response predictors in HNSCC patients treated with intensity modulated radiation therapy (IMRT). Methods In total 48 HNSCC patients treated by definitive IMRT were enrolled in our prospective study. To identify predictive salivary miRNAs, we used small RNA sequencing in 14 saliva samples of HNSCC patients and qRT-PCR validation of selected miRNA candidates in an independent set of 34 patients. Results We found that salivary miR-15a-5p and miR-15b-5p exhibited differential levels between patients with and without complete remission (p = 0.025 and p = 0.028, respectively). Subsequent Kaplan-Meier analysis confirmed that patients with higher levels of miR-15a-5p reached a significantly longer locoregional progression-free survival (LPFS) than those with low levels (p = 0.024). Finally, multivariate Cox regression analysis revealed that miR-15a-5p may serve as an independent predictive biomarker of LPFS in HNSCC patients treated with IMRT (HR 0.104; 95% CI 0.004-0.911; p = 0.04). Conclusions We conclude that salivary miR-15a-5p may represent a potential biomarker for individualized treatment decision-making in HNSCC patients.
ER -
AHMAD, Parwez, Marek SLÁVIK, Karolína TRACHTOVÁ, Natalia Anna GABŁO, Tomáš KAZDA, Dominik GURÍN, Pavel SMILEK, Zuzana HORÁKOVÁ, Břetislav GÁL, Markéta HERMANOVÁ, Pavel ŠLAMPA, Jiří ŠÁNA and Ondřej SLABÝ. Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients. \textit{CELLULAR ONCOLOGY}. DORDRECHT: SPRINGER, 2020, vol.~43, No~3, p.~505-511. ISSN~2211-3428. Available from: https://dx.doi.org/10.1007/s13402-020-00507-7.
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