Mechanisms and incidence of torsades de pointes tachycardia

C 2020

Mechanisms and incidence of torsades de pointes tachycardia

NOVOTNÝ, Tomáš

Základní údaje

Originální název

Mechanisms and incidence of torsades de pointes tachycardia

Autoři

NOVOTNÝ, Tomáš (203 Česká republika, garant, domácí)

Vydání

1st edition. Neuveden, Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women, od s. 303-308, 6 s. 2020

Nakladatel

Academic Press

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Odkazy

URL

Kód RIV

RIV/00216224:14110/20:00118093

Organizační jednotka

Lékařská fakulta

ISBN

978-0-12-817728-0

DOI

http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7

Klíčová slova anglicky

Afterdepolarization; Polymorphic ventricular tachycardia; Re-entry; Sex differences; Torsades de pointes

Štítky

rivok, topvydavatel

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 2. 2021 10:15, Mgr. Tereza Miškechová

Anotace

V originále

Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.

Citovat

NOVOTNÝ, Tomáš. Mechanisms and incidence of torsades de pointes tachycardia. In Marek Malík. Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women. 1st edition. Neuveden: Academic Press, 2020, s. 303-308. ISBN 978-0-12-817728-0. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7.

@inbook{1737280,
   author = {Novotný, Tomáš},
   address = {Neuveden},
   booktitle = {Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women},
   doi = {http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7},
   edition = {1st edition},
   editor = {Marek Malík},
   keywords = {Afterdepolarization; Polymorphic ventricular tachycardia; Re-entry; Sex differences; Torsades de pointes},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Neuveden},
   isbn = {978-0-12-817728-0},
   pages = {303-308},
   publisher = {Academic Press},
   title = {Mechanisms and incidence of torsades de pointes tachycardia},
   url = {https://www.sciencedirect.com/science/article/pii/B9780128177280000267},
   year = {2020}
}

TY  - CHAP
ID  - 1737280
AU  - Novotný, Tomáš
PY  - 2020
TI  - Mechanisms and incidence of torsades de pointes tachycardia
VL  - Neuveden
PB  - Academic Press
CY  - Neuveden
SN  - 9780128177280
KW  - Afterdepolarization
KW  - Polymorphic ventricular tachycardia
KW  - Re-entry
KW  - Sex differences
KW  - Torsades de pointes
UR  - https://www.sciencedirect.com/science/article/pii/B9780128177280000267
L2  - https://www.sciencedirect.com/science/article/pii/B9780128177280000267
N2  - Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.
ER  -

NOVOTNÝ, Tomáš. Mechanisms and incidence of torsades de pointes tachycardia. In Marek Malík. \textit{Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women}. 1st edition. Neuveden: Academic Press, 2020, s.~303-308. ISBN~978-0-12-817728-0. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7.

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