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@inbook{1737280, author = {Novotný, Tomáš}, address = {Neuveden}, booktitle = {Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women}, doi = {http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7}, edition = {1st edition}, editor = {Marek Malík}, keywords = {Afterdepolarization; Polymorphic ventricular tachycardia; Re-entry; Sex differences; Torsades de pointes}, howpublished = {tištěná verze "print"}, language = {eng}, location = {Neuveden}, isbn = {978-0-12-817728-0}, pages = {303-308}, publisher = {Academic Press}, title = {Mechanisms and incidence of torsades de pointes tachycardia}, url = {https://www.sciencedirect.com/science/article/pii/B9780128177280000267}, year = {2020} }
TY - CHAP ID - 1737280 AU - Novotný, Tomáš PY - 2020 TI - Mechanisms and incidence of torsades de pointes tachycardia VL - Neuveden PB - Academic Press CY - Neuveden SN - 9780128177280 KW - Afterdepolarization KW - Polymorphic ventricular tachycardia KW - Re-entry KW - Sex differences KW - Torsades de pointes UR - https://www.sciencedirect.com/science/article/pii/B9780128177280000267 L2 - https://www.sciencedirect.com/science/article/pii/B9780128177280000267 N2 - Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women. ER -
NOVOTNÝ, Tomáš. Mechanisms and incidence of torsades de pointes tachycardia. In Marek Malík. \textit{Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women}. 1st edition. Neuveden: Academic Press, 2020, s.~303-308. ISBN~978-0-12-817728-0. Dostupné z: https://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7.
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