(Hetero)Aryloxyaminopropanols with N-Phenylpiperazine
Structural Fragment - Review of Cardiovascular Activity

J 2020

(Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity

MARVANOVÁ, Pavlína, Tereza PADRTOVÁ a Petr MOKRÝ

Základní údaje

Originální název

(Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity

Autoři

MARVANOVÁ, Pavlína (203 Česká republika, garant, domácí), Tereza PADRTOVÁ (203 Česká republika) a Petr MOKRÝ (203 Česká republika)

Vydání

Mini-reviews in medicinal chemistry, Sharjah, Betham Science Publ Ltd. 2020, 1389-5575

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.862

Kód RIV

RIV/00216224:14160/20:00118111

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.2174/1389557520666200624192859

UT WoS

000591916700003

Klíčová slova anglicky

Aryloxyphenylpiperazinylpropanols; cardiovascular system; chirality; connecting chain modification; N-phenylpiperazine; biological activities

Štítky

rivok, ÚChL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 2. 2021 07:53, Mgr. Hana Hurtová

Anotace

V originále

Aryloxyphenylpiperazinylpropanols are a group of compounds exhibiting a wide range of biological activities, affecting the central nervous system and many cardiovascular mechanisms among them. As cardiovascular agents, aryloxyphenylpiperazinylpropanols work as antihypertensives, antiarrhythmics, cardiotonics or antiaggregants. The mechanism of action is almost always an alpha(1)-adrenolytic or combined alpha(1)- and beta-adrenolytic effect, but sometimes other mechanisms (e.g., Ca2+ antagonism or phosphodiesterase inhibition) can positively participate. In some cases, compounds with a small modification of the connecting chain also exhibit the desired cardiovascular effects. Several studies dealt with chirality of aryloxyphenylpiperazinylpropanols and determined the differences between the particular activities of racemic and enantiomeric compounds.

Citovat

MARVANOVÁ, Pavlína, Tereza PADRTOVÁ a Petr MOKRÝ. (Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity. Mini-reviews in medicinal chemistry. Sharjah: Betham Science Publ Ltd., 2020, roč. 20, č. 17, s. 1719-1731. ISSN 1389-5575. Dostupné z: https://dx.doi.org/10.2174/1389557520666200624192859.

@article{1738507,
   author = {Marvanová, Pavlína and Padrtová, Tereza and Mokrý, Petr},
   article_location = {Sharjah},
   article_number = {17},
   doi = {http://dx.doi.org/10.2174/1389557520666200624192859},
   keywords = {Aryloxyphenylpiperazinylpropanols; cardiovascular system; chirality; connecting chain modification; N-phenylpiperazine; biological activities},
   language = {eng},
   issn = {1389-5575},
   journal = {Mini-reviews in medicinal chemistry},
   title = {(Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity},
   url = {https://pubmed.ncbi.nlm.nih.gov/32579495/},
   volume = {20},
   year = {2020}
}

TY  - JOUR
ID  - 1738507
AU  - Marvanová, Pavlína - Padrtová, Tereza - Mokrý, Petr
PY  - 2020
TI  - (Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity
JF  - Mini-reviews in medicinal chemistry
VL  - 20
IS  - 17
SP  - 1719-1731
EP  - 1719-1731
PB  - Betham Science Publ Ltd.
SN  - 13895575
KW  - Aryloxyphenylpiperazinylpropanols
KW  - cardiovascular system
KW  - chirality
KW  - connecting chain modification
KW  - N-phenylpiperazine
KW  - biological activities
UR  - https://pubmed.ncbi.nlm.nih.gov/32579495/
L2  - https://pubmed.ncbi.nlm.nih.gov/32579495/
N2  - Aryloxyphenylpiperazinylpropanols are a group of compounds exhibiting a wide range of biological activities, affecting the central nervous system and many cardiovascular mechanisms among them. As cardiovascular agents, aryloxyphenylpiperazinylpropanols work as antihypertensives, antiarrhythmics, cardiotonics or antiaggregants. The mechanism of action is almost always an alpha(1)-adrenolytic or combined alpha(1)- and beta-adrenolytic effect, but sometimes other mechanisms (e.g., Ca2+ antagonism or phosphodiesterase inhibition) can positively participate. In some cases, compounds with a small modification of the connecting chain also exhibit the desired cardiovascular effects. Several studies dealt with chirality of aryloxyphenylpiperazinylpropanols and determined the differences between the particular activities of racemic and enantiomeric compounds.
ER  -

MARVANOVÁ, Pavlína, Tereza PADRTOVÁ a Petr MOKRÝ. (Hetero)Aryloxyaminopropanols with N-Phenylpiperazine Structural Fragment - Review of Cardiovascular Activity. \textit{Mini-reviews in medicinal chemistry}. Sharjah: Betham Science Publ Ltd., 2020, roč.~20, č.~17, s.~1719-1731. ISSN~1389-5575. Dostupné z: https://dx.doi.org/10.2174/1389557520666200624192859.

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