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@article{1738511,
author = {Elbl, Jan and Gajdziok, Jan and Kolarczyk, J.},
article_location = {AMSTERDAM},
article_number = {118883},
doi = {http://dx.doi.org/10.1016/j.ijpharm.2019.118883},
keywords = {Orodispersible films; 3D printing; Benzydamine hydrochloride; Multilayer; Personalization},
language = {eng},
issn = {0378-5173},
journal = {International Journal of Pharmaceutics},
title = {3D printing of multilayered orodispersible films with in-process drying},
url = {https://www.sciencedirect.com/science/article/pii/S0378517319309287},
volume = {575},
year = {2020}
}
TY - JOUR
ID - 1738511
AU - Elbl, Jan - Gajdziok, Jan - Kolarczyk, J.
PY - 2020
TI - 3D printing of multilayered orodispersible films with in-process drying
JF - International Journal of Pharmaceutics
VL - 575
IS - 118883
SP - 1-8
EP - 1-8
PB - ELSEVIER SCIENCE BV
SN - 03785173
KW - Orodispersible films
KW - 3D printing
KW - Benzydamine hydrochloride
KW - Multilayer
KW - Personalization
UR - https://www.sciencedirect.com/science/article/pii/S0378517319309287
L2 - https://www.sciencedirect.com/science/article/pii/S0378517319309287
N2 - The aim of this study was to prepare benzydamine hydrochloride loaded orodispersible films using modified semisolid extrusion 3D printing method. An innovative approach was developed where thin layer of drug loaded dispersion is printed and dried before printing of subsequent layers. Layer-by-layer drying as the in process step improves mechanical properties of films, uniformity of drug content and allows faster preparation of films in compounding settings due to shortening of drying time. Orodispersible films consisted of film forming maltodextrin, sorbitol as a plasticizer and hydroxyethylcellulose as a thickening agent. The height of the digital model showed excellent correlation with the disintegration time, weight, thickness and mechanical properties of prepared films. Drug content, predefined by volume of digital model and concentration of drug in print dispersion, showed excellent uniformity. The modified printing method shows great promise in a compounding production of personalized film dosage forms, and brings in possibilities such as one step preparation of films with compartmented drugs and incorporation of taste masking or release control layers.
ER -
ELBL, Jan, Jan GAJDZIOK and J. KOLARCZYK. 3D printing of multilayered orodispersible films with in-process drying. \textit{International Journal of Pharmaceutics}. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, vol.~575, No~118883, p.~1-8. ISSN~0378-5173. Available from: https://dx.doi.org/10.1016/j.ijpharm.2019.118883.
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