The role of the combined use of experimental and computational
methods in revealing the differences between the micron -size
particle deposition patterns in healthy and asthmatic subjects

J 2020

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS et. al.

Základní údaje

Originální název

The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects

Autoři

FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS (203 Česká republika, domácí), M. BELKA, O. MISIK a M. JICHA

Vydání

Journal of Aerosol Science, OXFORD, ELSEVIER SCI LTD, 2020, 0021-8502

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.433

Kód RIV

RIV/00216224:14160/20:00118115

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1016/j.jaerosci.2020.105582

UT WoS

000540032700004

Klíčová slova anglicky

AEROSOL DEPOSITION; HUMAN AIRWAYS; LUNG-FUNCTION; FLOW

Štítky

rivok, ÚFT

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 2. 2021 08:38, Mgr. Hana Hurtová

Anotace

ORIG CZ

V originále

Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively.

Česky

Citovat

FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS, M. BELKA, O. MISIK a M. JICHA. The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects. Journal of Aerosol Science. OXFORD: ELSEVIER SCI LTD, 2020, roč. 147, č. 105582, s. 1-16. ISSN 0021-8502. Dostupné z: https://dx.doi.org/10.1016/j.jaerosci.2020.105582.

@article{1738519,
   author = {Farkas, A. and Lizal, F. and Jedelsky, J. and Elcner, J. and Karas, Jakub and Belka, M. and Misik, O. and Jicha, M.},
   article_location = {OXFORD},
   article_number = {105582},
   doi = {http://dx.doi.org/10.1016/j.jaerosci.2020.105582},
   keywords = {AEROSOL DEPOSITION; HUMAN AIRWAYS; LUNG-FUNCTION; FLOW},
   language = {eng},
   issn = {0021-8502},
   journal = {Journal of Aerosol Science},
   title = {The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects},
   url = {https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub},
   volume = {147},
   year = {2020}
}

TY  - JOUR
ID  - 1738519
AU  - Farkas, A. - Lizal, F. - Jedelsky, J. - Elcner, J. - Karas, Jakub - Belka, M. - Misik, O. - Jicha, M.
PY  - 2020
TI  - The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects
JF  - Journal of Aerosol Science
VL  - 147
IS  - 105582
SP  - 1-16
EP  - 1-16
PB  - ELSEVIER SCI LTD
SN  - 00218502
KW  - AEROSOL DEPOSITION
KW  - HUMAN AIRWAYS
KW  - LUNG-FUNCTION
KW  - FLOW
UR  - https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0021850220300719?via%3Dihub
N2  - Quantification of airway deposition of aerosol particles is essential for the assessment of health risks of detrimental particles. Knowledge of deposition distribution is important also in the case of treatment with aerosolised drugs. It is also worth considering that deposition of inhaled particles in severe asthmatics can be different from the deposition in healthy subjects due to the modified breathing parameters, airway geometry and lobar flow distribution. The aim of this study was to apply combined experimental and numerical techniques to quantify the upper airway and bronchial deposition of the inhaled microparticles in healthy individuals in comparison with asthma patients. Idealised and realistic physical and digital replicas of the human airways were constructed. Deposition fractions and efficiencies of inhaled polydisperse mannitol and chitosan particles in different airway sections were measured and calculated. Deposition fraction of polydisperse mannitol particles in the idealised airway geometry assuming breathing conditions of healthy subjects was 21.9% and 18.3% when determined experimentally and by numerical simulations, respectively. Experimental measurements of deposition fraction of chitosan particles in the same geometry, but assuming breathing parameters characteristic of severe asthmatics yielded 32%, while simulations provided 30.1% for the same conditions. Extrathoracic deposition fraction of mannitol particles in healthy subjects measured in the realistic geometry was 71.1%, while bronchial deposition fraction was 5.3%. The corresponding simulations yielded 76.2% and 8.9% deposition fractions in the upper and bronchial airways, respectively.
ER  -

FARKAS, A., F. LIZAL, J. JEDELSKY, J. ELCNER, Jakub KARAS, M. BELKA, O. MISIK a M. JICHA. The role of the combined use of experimental and computational methods in revealing the differences between the micron -size particle deposition patterns in healthy and asthmatic subjects. \textit{Journal of Aerosol Science}. OXFORD: ELSEVIER SCI LTD, 2020, roč.~147, č.~105582, s.~1-16. ISSN~0021-8502. Dostupné z: https://dx.doi.org/10.1016/j.jaerosci.2020.105582.

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