Multi-pathogen infections and Alzheimer's disease

J 2021

Multi-pathogen infections and Alzheimer's disease

VIGAŠOVÁ, Dana, Michal NEMERGUT, Barbora LIŠKOVÁ a Jiří DAMBORSKÝ

Základní údaje

Originální název

Multi-pathogen infections and Alzheimer's disease

Autoři

VIGAŠOVÁ, Dana (703 Slovensko, garant, domácí), Michal NEMERGUT (703 Slovensko, domácí), Barbora LIŠKOVÁ (203 Česká republika, domácí) a Jiří DAMBORSKÝ (203 Česká republika, domácí)

Vydání

Microbial Cell Factories, London, BioMed Central Ltd, 2021, 1475-2859

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10603 Genetics and heredity

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.352

Kód RIV

RIV/00216224:14310/21:00119789

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1186/s12934-021-01520-7

UT WoS

000616106500001

Klíčová slova anglicky

Alzheimer’s disease; Antibacterial; Anti-biofilm; Antifungal; Antiviral; Bacteria; Infectious burden; Parasites; Pathogens; Viruses

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 15. 2. 2023 23:38, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-beta peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechanism of AD pathogenesis, the underlying cause of AD is not fully understood. No disease-modifying therapies currently exist, and numerous clinical trials have failed to demonstrate any benefits. The recent discovery that the amyloid-beta peptide has antimicrobial activities supports the possibility of an infectious aetiology of AD and suggests that amyloid-beta plaque formation might be induced by infection. AD patients have a weakened blood-brain barrier and immune system and are thus at elevated risk of microbial infections. Such infections can cause chronic neuroinflammation, production of the antimicrobial amyloid-beta peptide, and neurodegeneration. Various pathogens, including viruses, bacteria, fungi, and parasites have been associated with AD. Most research in this area has focused on individual pathogens, with herpesviruses and periodontal bacteria being most frequently implicated. The purpose of this review is to highlight the potential role of multi-pathogen infections in AD. Recognition of the potential coexistence of multiple pathogens and biofilms in AD's aetiology may stimulate the development of novel approaches to its diagnosis and treatment. Multiple diagnostic tests could be applied simultaneously to detect major pathogens, followed by anti-microbial treatment using antiviral, antibacterial, antifungal, and anti-biofilm agents.

Návaznosti

TN01000013, projekt VaV

Název: Personalizovaná medicína - diagnostika a terapie

Investor: Technologická agentura ČR, Personalizovaná medicína - diagnostika a terapie

814418, interní kód MU

Název: Synthetic biology-guided engineering of Pseudomonas putida for biofluorination (Akronym: SinFonia)

Investor: Evropská unie, Synthetic biology-guided engineering of Pseudomonas putida for biofluorination, Leadership in enabling and industrial technologies (LEIT) (Industrial Leadership)

Přiložené soubory

1739777.pdf

Vyhledat podobné dokumenty

Citovat

VIGAŠOVÁ, Dana, Michal NEMERGUT, Barbora LIŠKOVÁ a Jiří DAMBORSKÝ. Multi-pathogen infections and Alzheimer's disease. Microbial Cell Factories. London: BioMed Central Ltd, 2021, roč. 20, č. 1, s. 25-37. ISSN 1475-2859. Dostupné z: https://dx.doi.org/10.1186/s12934-021-01520-7.

@article{1739777,
   author = {Vigašová, Dana and Nemergut, Michal and Lišková, Barbora and Damborský, Jiří},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12934-021-01520-7},
   keywords = {Alzheimer’s disease; Antibacterial; Anti-biofilm; Antifungal; Antiviral; Bacteria; Infectious burden; Parasites; Pathogens; Viruses},
   language = {eng},
   issn = {1475-2859},
   journal = {Microbial Cell Factories},
   title = {Multi-pathogen infections and Alzheimer's disease},
   url = {https://doi.org/10.1186/s12934-021-01520-7},
   volume = {20},
   year = {2021}
}

TY  - JOUR
ID  - 1739777
AU  - Vigašová, Dana - Nemergut, Michal - Lišková, Barbora - Damborský, Jiří
PY  - 2021
TI  - Multi-pathogen infections and Alzheimer's disease
JF  - Microbial Cell Factories
VL  - 20
IS  - 1
SP  - 25
EP  - 25
PB  - BioMed Central Ltd
SN  - 14752859
KW  - Alzheimer’s disease
KW  - Antibacterial
KW  - Anti-biofilm
KW  - Antifungal
KW  - Antiviral
KW  - Bacteria
KW  - Infectious burden
KW  - Parasites
KW  - Pathogens
KW  - Viruses
UR  - https://doi.org/10.1186/s12934-021-01520-7
L2  - https://doi.org/10.1186/s12934-021-01520-7
N2  - Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with the overproduction and accumulation of amyloid-beta peptide and hyperphosphorylation of tau proteins in the brain. Despite extensive research on the amyloid-based mechanism of AD pathogenesis, the underlying cause of AD is not fully understood. No disease-modifying therapies currently exist, and numerous clinical trials have failed to demonstrate any benefits. The recent discovery that the amyloid-beta peptide has antimicrobial activities supports the possibility of an infectious aetiology of AD and suggests that amyloid-beta plaque formation might be induced by infection. AD patients have a weakened blood-brain barrier and immune system and are thus at elevated risk of microbial infections. Such infections can cause chronic neuroinflammation, production of the antimicrobial amyloid-beta peptide, and neurodegeneration. Various pathogens, including viruses, bacteria, fungi, and parasites have been associated with AD. Most research in this area has focused on individual pathogens, with herpesviruses and periodontal bacteria being most frequently implicated. The purpose of this review is to highlight the potential role of multi-pathogen infections in AD. Recognition of the potential coexistence of multiple pathogens and biofilms in AD's aetiology may stimulate the development of novel approaches to its diagnosis and treatment. Multiple diagnostic tests could be applied simultaneously to detect major pathogens, followed by anti-microbial treatment using antiviral, antibacterial, antifungal, and anti-biofilm agents.
ER  -

VIGAŠOVÁ, Dana, Michal NEMERGUT, Barbora LIŠKOVÁ a Jiří DAMBORSKÝ. Multi-pathogen infections and Alzheimer's disease. \textit{Microbial Cell Factories}. London: BioMed Central Ltd, 2021, roč.~20, č.~1, s.~25-37. ISSN~1475-2859. Dostupné z: https://dx.doi.org/10.1186/s12934-021-01520-7.

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