| LEEKSMA, A. C., P. BALIAKAS, T. MOYSIADIS, A. PUIGGROS, Karla PLEVOVÁ, A. M. VAND ER KEVIE-KERSEMAEKERS, H. POSTHUMA, A. E. RODRIGUEZ-VICENTE, A. N. TRAN, G. BARBANY, L. MANSOURI, R. GUNNARSSON, H. PARKER, E. VAN DEN BERG, M. BELLIDO, Z. DAVIS, M. WALL, I. SCARPELLI, A. OSTERBORG, L. HANSSON, Marie JAROŠOVÁ, P. GHIA, P. PODDIGHE, B. ESPINET, Šárka POSPÍŠILOVÁ, C. TAM, L. YSEBAERT, F. NGUYEN-KHAC, D. OSCIER, C. HAFERLACH, J. SCHOUMANS, M. STEVENS-KROEF, E. ELDERING, K. STAMATOPOULOS, R. ROSENQUIST, J. C. STREFFORD, C. MELLINK and A. P. KATER. Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study. Haematologica. PAVIA: FERRATA STORTI FOUNDATION, 2021, vol. 106, No 1, p. 87-97. ISSN 0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2019.239947. |
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@article{1739856,
author = {Leeksma, A. C. and Baliakas, P. and Moysiadis, T. and Puiggros, A. and Plevová, Karla and vand er KevieandKersemaekers, A. M. and Posthuma, H. and RodriguezandVicente, A. E. and Tran, A. N. and Barbany, G. and Mansouri, L. and Gunnarsson, R. and Parker, H. and van den Berg, E. and Bellido, M. and Davis, Z. and Wall, M. and Scarpelli, I. and Osterborg, A. and Hansson, L. and Jarošová, Marie and Ghia, P. and Poddighe, P. and Espinet, B. and Pospíšilová, Šárka and Tam, C. and Ysebaert, L. and NguyenandKhac, F. and Oscier, D. and Haferlach, C. and Schoumans, J. and StevensandKroef, M. and Eldering, E. and Stamatopoulos, K. and Rosenquist, R. and Strefford, J. C. and Mellink, C. and Kater, A. P.},
article_location = {PAVIA},
article_number = {1},
doi = {http://dx.doi.org/10.3324/haematol.2019.239947},
keywords = {Genomic arrays; chronic lymphocytic leukemia},
language = {eng},
issn = {0390-6078},
journal = {Haematologica},
title = {Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study},
url = {https://haematologica.org/article/view/9623},
volume = {106},
year = {2021}
}
TY - JOUR
ID - 1739856
AU - Leeksma, A. C. - Baliakas, P. - Moysiadis, T. - Puiggros, A. - Plevová, Karla - vand er Kevie-Kersemaekers, A. M. - Posthuma, H. - Rodriguez-Vicente, A. E. - Tran, A. N. - Barbany, G. - Mansouri, L. - Gunnarsson, R. - Parker, H. - van den Berg, E. - Bellido, M. - Davis, Z. - Wall, M. - Scarpelli, I. - Osterborg, A. - Hansson, L. - Jarošová, Marie - Ghia, P. - Poddighe, P. - Espinet, B. - Pospíšilová, Šárka - Tam, C. - Ysebaert, L. - Nguyen-Khac, F. - Oscier, D. - Haferlach, C. - Schoumans, J. - Stevens-Kroef, M. - Eldering, E. - Stamatopoulos, K. - Rosenquist, R. - Strefford, J. C. - Mellink, C. - Kater, A. P.
PY - 2021
TI - Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study
JF - Haematologica
VL - 106
IS - 1
SP - 87-97
EP - 87-97
PB - FERRATA STORTI FOUNDATION
SN - 03906078
KW - Genomic arrays
KW - chronic lymphocytic leukemia
UR - https://haematologica.org/article/view/9623
L2 - https://haematologica.org/article/view/9623
N2 - Complex karyotype identified by chromosome-banding analysis has been shown to have prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high-resolution genomewide detection of copy-number alterations (CNA) and could therefore be well equipped to detect the presence of a complex karyotype. Current knowledge on genomic arrays in CLL is based on outcomes of single-cen ter studies, in which different cutoffs for CNA calling were used. To further determine the clinical utility of genomic arrays for CNA assessment in CLL diagnostics, we retrospectively analyzed 2,293 arrays from 13 diagnostic laboratories according to established standards. CNA were found outside regions captured by CLL fluorescence in situ hybridization probes in 34% of patients, and several of them, including gains of 8q, deletions of 9p and 18p (P<0.01), were linked to poor outcome after correction for multiple testing. Patients (n=972) could be divided into three distinct prognostic subgroups based on the number of CNA. In multivariable analysis only high genomic complexity, defined as z5 CNA, emerged as an independent adverse prognosticator for time to first treatment (hazard ratio: 2.15; 95% confidence interval: 1.36-3.41; P=0.001) and overall survival (hazard ratio: 2.54, 95% confidence interval: 1.54-4.17; P<0.001; n=528). Lowering the size cutoff to 1 Mb in 647 patients did not significantly improve risk assessment. Genomic arrays detected more chromosomal abnormalities and, in terms of risk stratification, performed at least as well as simultaneous chromosome banding analysis as carried out in 122 patients. Our findings indicate that genomic array is an accurate tool for CLL risk stratification.
ER -
LEEKSMA, A. C., P. BALIAKAS, T. MOYSIADIS, A. PUIGGROS, Karla PLEVOVÁ, A. M. VAND ER KEVIE-KERSEMAEKERS, H. POSTHUMA, A. E. RODRIGUEZ-VICENTE, A. N. TRAN, G. BARBANY, L. MANSOURI, R. GUNNARSSON, H. PARKER, E. VAN DEN BERG, M. BELLIDO, Z. DAVIS, M. WALL, I. SCARPELLI, A. OSTERBORG, L. HANSSON, Marie JAROŠOVÁ, P. GHIA, P. PODDIGHE, B. ESPINET, Šárka POSPÍŠILOVÁ, C. TAM, L. YSEBAERT, F. NGUYEN-KHAC, D. OSCIER, C. HAFERLACH, J. SCHOUMANS, M. STEVENS-KROEF, E. ELDERING, K. STAMATOPOULOS, R. ROSENQUIST, J. C. STREFFORD, C. MELLINK and A. P. KATER. Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2021, vol.~106, No~1, p.~87-97. ISSN~0390-6078. Available from: https://dx.doi.org/10.3324/haematol.2019.239947.
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