Predictive and prognostic significance of tumour subtype,
SSTR1-5 and e-cadherin expression in a well-defined cohort of
patients with acromegaly

J 2021

Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly

SOUKUP, Jiri, Helena HORNYCHOVA, Monika MANETHOVA, Kvetoslava MICHALOVA, Ludmila MICHNOVA et. al.

Základní údaje

Originální název

Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly

Autoři

SOUKUP, Jiri (203 Česká republika), Helena HORNYCHOVA (203 Česká republika), Monika MANETHOVA (203 Česká republika), Kvetoslava MICHALOVA (203 Česká republika), Ludmila MICHNOVA (203 Česká republika), Lenka POPOVSKA (203 Česká republika), Veronika SKARKOVA (203 Česká republika), Tomas CESAK (203 Česká republika), David NETUKA (203 Česká republika), Ales RYSKA (203 Česká republika), Jan CAP (203 Česká republika), Vaclav HANA (203 Česká republika), Vaclav, Jr. HANA (203 Česká republika), Michal KRSEK (203 Česká republika), Eva DVORAKOVA (203 Česká republika), Michal KRCMA (203 Česká republika), Ivica LAZUROVA (703 Slovensko), Věra OLŠOVSKÁ (203 Česká republika, domácí), Karel STARÝ (203 Česká republika, domácí), Peter VANUGA (703 Slovensko) a Filip GABALEC (203 Česká republika)

Vydání

Journal of Cellular and Molecular Medicine, HOBOKEN, Wiley Blackwell, 2021, 1582-1838

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.295

Kód RIV

RIV/00216224:14110/21:00121110

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/jcmm.16173

UT WoS

000610837800001

Klíčová slova anglicky

acromegaly; PITNET; pituitary neoplasm; somatostatin receptor

Štítky

14110116, 14110213, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 6. 2021 14:23, Mgr. Tereza Miškechová

Anotace

V originále

In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered. Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.

Citovat

SOUKUP, Jiri, Helena HORNYCHOVA, Monika MANETHOVA, Kvetoslava MICHALOVA, Ludmila MICHNOVA, Lenka POPOVSKA, Veronika SKARKOVA, Tomas CESAK, David NETUKA, Ales RYSKA, Jan CAP, Vaclav HANA, Vaclav, Jr. HANA, Michal KRSEK, Eva DVORAKOVA, Michal KRCMA, Ivica LAZUROVA, Věra OLŠOVSKÁ, Karel STARÝ, Peter VANUGA a Filip GABALEC. Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly. Journal of Cellular and Molecular Medicine. HOBOKEN: Wiley Blackwell, 2021, roč. 25, č. 5, s. 2484-2492. ISSN 1582-1838. Dostupné z: https://dx.doi.org/10.1111/jcmm.16173.

@article{1739876,
   author = {Soukup, Jiri and Hornychova, Helena and Manethova, Monika and Michalova, Kvetoslava and Michnova, Ludmila and Popovska, Lenka and Skarkova, Veronika and Cesak, Tomas and Netuka, David and Ryska, Ales and Cap, Jan and Hana, Vaclav and Hana, Vaclav, Jr. and Krsek, Michal and Dvorakova, Eva and Krcma, Michal and Lazurova, Ivica and Olšovská, Věra and Starý, Karel and Vanuga, Peter and Gabalec, Filip},
   article_location = {HOBOKEN},
   article_number = {5},
   doi = {http://dx.doi.org/10.1111/jcmm.16173},
   keywords = {acromegaly; PITNET; pituitary neoplasm; somatostatin receptor},
   language = {eng},
   issn = {1582-1838},
   journal = {Journal of Cellular and Molecular Medicine},
   title = {Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly},
   url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173},
   volume = {25},
   year = {2021}
}

TY  - JOUR
ID  - 1739876
AU  - Soukup, Jiri - Hornychova, Helena - Manethova, Monika - Michalova, Kvetoslava - Michnova, Ludmila - Popovska, Lenka - Skarkova, Veronika - Cesak, Tomas - Netuka, David - Ryska, Ales - Cap, Jan - Hana, Vaclav - Hana, Vaclav, Jr. - Krsek, Michal - Dvorakova, Eva - Krcma, Michal - Lazurova, Ivica - Olšovská, Věra - Starý, Karel - Vanuga, Peter - Gabalec, Filip
PY  - 2021
TI  - Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly
JF  - Journal of Cellular and Molecular Medicine
VL  - 25
IS  - 5
SP  - 2484-2492
EP  - 2484-2492
PB  - Wiley Blackwell
SN  - 15821838
KW  - acromegaly
KW  - PITNET
KW  - pituitary neoplasm
KW  - somatostatin receptor
UR  - https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173
L2  - https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.16173
N2  - In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered. Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly.
ER  -

SOUKUP, Jiri, Helena HORNYCHOVA, Monika MANETHOVA, Kvetoslava MICHALOVA, Ludmila MICHNOVA, Lenka POPOVSKA, Veronika SKARKOVA, Tomas CESAK, David NETUKA, Ales RYSKA, Jan CAP, Vaclav HANA, Vaclav, Jr. HANA, Michal KRSEK, Eva DVORAKOVA, Michal KRCMA, Ivica LAZUROVA, Věra OLŠOVSKÁ, Karel STARÝ, Peter VANUGA a Filip GABALEC. Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly. \textit{Journal of Cellular and Molecular Medicine}. HOBOKEN: Wiley Blackwell, 2021, roč.~25, č.~5, s.~2484-2492. ISSN~1582-1838. Dostupné z: https://dx.doi.org/10.1111/jcmm.16173.

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