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@proceedings{1740586, author = {Tesarova, S and Blaha, V and Ceska, R and Dvorakova, J and Freiberger, Tomáš and Horak, P and Hyanek, J and Kyselák, Ondřej and Nussbaumerova, B and Soska, V and Urbanek, R and Vaclova, M and Vaverkova, H and Vrablik, M and Vyroubal, P and Zemek, S and Zlatohlavek, L}, doi = {http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.541}, language = {eng}, title = {GENERAL CHARACTERISTICS OF PACIENTS WITH HOMOZYGOUS FORM OF FAMILIAL HYPERCHOLESTEROLAEMIA IN THE CZECH REPUBLIC}, url = {https://www.sciencedirect.com/science/article/pii/S0021915018308530?via%3Dihub}, year = {2018} }
TY - CONF ID - 1740586 AU - Tesarova, S - Blaha, V - Ceska, R - Dvorakova, J - Freiberger, Tomáš - Horak, P - Hyanek, J - Kyselák, Ondřej - Nussbaumerova, B - Soska, V - Urbanek, R - Vaclova, M - Vaverkova, H - Vrablik, M - Vyroubal, P - Zemek, S - Zlatohlavek, L PY - 2018 TI - GENERAL CHARACTERISTICS OF PACIENTS WITH HOMOZYGOUS FORM OF FAMILIAL HYPERCHOLESTEROLAEMIA IN THE CZECH REPUBLIC UR - https://www.sciencedirect.com/science/article/pii/S0021915018308530?via%3Dihub N2 - Aim: Aim of project was to define general characteristics of patients with homozygous form of familial hypercholesterolaemia in the Czech Republic. Methods: Set of hoFH patients has 19 patients, including 5 ceased. Patients were selected by the genetic testing or phenotypic criteria for hoFH. Data were extracted from the Czech national FH registry (MedPed). Results: Median of age at diagnosis was 30,0; R(7-63) years. Baseline total cholesterol (T-C) level had median 12.85; R(6.4-22.8)mmol/l and LDL-cholesterol (LDL-C) 10.27; R(4.29-21.26)mmol/l. 18 homozygotes were confirmed by genotyping – 77.8% of patients had LDLR/LDLR mutation and 22.2% had apoB/apoB mutation. All of the patients with apoB mutation are true homozygotes, while only 4 patients with LDLR mutation were true homozygotes and 10 patients were compound heterozygotes. There were no double heterozygotes. Premature atherosclerotic vascular disease was diagnosed in 74%, xanthomas in 37%, arcus lipoides corneae in 11% and xanthelasma in 16% cases. 5 patients died, median age of death was 45; R(32-68) years. All patients were treated with statins, 93% had a statin-ezetimibe combination, 50% were on triple therapy with PCSK9-i, 5 patients had regular LDL-apheresis. Median of on-treatment LDL-C was 3.64; R(1.04-6.03)mmol/l. Patients with LDLR/LDLR mutation compared to apoB/apoB homozygotes have better on-treatment levels of LDL-C and T-C, even though the baseline LDL-C and T-C levels were higher. 33% patients reached LDL-C targets. Conclusions: Our study demonstrated important clinical and laboratory differences between LDLR and apoB FH homozygous individuals including target values attainment variability. ER -
TESAROVA, S, V BLAHA, R CESKA, J DVORAKOVA, Tomáš FREIBERGER, P HORAK, J HYANEK, Ondřej KYSELÁK, B NUSSBAUMEROVA, V SOSKA, R URBANEK, M VACLOVA, H VAVERKOVA, M VRABLIK, P VYROUBAL, S ZEMEK a L ZLATOHLAVEK. \textit{GENERAL CHARACTERISTICS OF PACIENTS WITH HOMOZYGOUS FORM OF FAMILIAL HYPERCHOLESTEROLAEMIA IN THE CZECH REPUBLIC}. 2018. Dostupné z: https://dx.doi.org/10.1016/j.atherosclerosis.2018.06.541.
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