| DAMBORSKÁ, Alena, Martin LAMOŠ, D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ, Barbora DEUTSCHOVÁ, Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. BRAIN TOPOGRAPHY. DORDRECHT: SPRINGER, 2021, vol. 34, No 3, p. 272-282. ISSN 0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00822-8. |
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@article{1742258,
author = {Damborská, Alena and Lamoš, Martin and Brunet, D. and Vulliemoz, S. and Bočková, Martina and Deutschová, Barbora and Baláž, Marek and Rektor, Ivan},
article_location = {DORDRECHT},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s10548-021-00822-8},
keywords = {Subthalamic nucleus; Subcortico-cortical interactions; Phase-amplitude coupling; Cross-structural coupling; Simultaneous intracranial and scalp EEG},
language = {eng},
issn = {0896-0267},
journal = {BRAIN TOPOGRAPHY},
title = {Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study},
url = {https://link.springer.com/article/10.1007/s10548-021-00822-8},
volume = {34},
year = {2021}
}
TY - JOUR
ID - 1742258
AU - Damborská, Alena - Lamoš, Martin - Brunet, D. - Vulliemoz, S. - Bočková, Martina - Deutschová, Barbora - Baláž, Marek - Rektor, Ivan
PY - 2021
TI - Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study
JF - BRAIN TOPOGRAPHY
VL - 34
IS - 3
SP - 272-282
EP - 272-282
PB - SPRINGER
SN - 08960267
KW - Subthalamic nucleus
KW - Subcortico-cortical interactions
KW - Phase-amplitude coupling
KW - Cross-structural coupling
KW - Simultaneous intracranial and scalp EEG
UR - https://link.springer.com/article/10.1007/s10548-021-00822-8
L2 - https://link.springer.com/article/10.1007/s10548-021-00822-8
N2 - It has been suggested that slow oscillations in the subthalamic nucleus (STN) reflect top-down inputs from the medial prefrontal cortex, thus implementing behavior control. It is unclear, however, whether the STN oscillations are related to cortical activity in a bottom-up manner. To assess resting-state subcortico-cortical interactions, we recorded simultaneous scalp electroencephalographic activity and local field potentials in the STN (LFP-STN) in 11 patients with Parkinson's disease implanted with deep brain stimulation electrodes in the on-medication state during rest. We assessed the cross-structural phase-amplitude coupling (PAC) between the STN and cortical activity within a wide frequency range of 1 to 100 Hz. The PAC was dominant between the delta/theta STN phase and beta/gamma cortical amplitude in most investigated scalp regions and between the delta cortical phase and theta/alpha STN amplitude in the frontal and temporal regions. The cross-frequency linkage between the slow oscillations of the LFP-STN activity and the amplitude of the scalp-recorded cortical activity at rest was demonstrated, and similar involvement of the left and right STNs in the coupling was observed. Our results suggest that the STN plays a role in both bottom-up and top-down processes within the subcortico-cortical circuitries of the human brain during the resting state. A relative left-right symmetry in the STN-cortex functional linkage was suggested. Practical treatment studies would be necessary to assess whether unilateral stimulation of the STN might be sufficient for treatment of Parkinson's disease.
ER -
DAMBORSKÁ, Alena, Martin LAMOŠ, D. BRUNET, S. VULLIEMOZ, Martina BOČKOVÁ, Barbora DEUTSCHOVÁ, Marek BALÁŽ and Ivan REKTOR. Resting-State Phase-Amplitude Coupling Between the Human Subthalamic Nucleus and Cortical Activity: A Simultaneous Intracranial and Scalp EEG Study. \textit{BRAIN TOPOGRAPHY}. DORDRECHT: SPRINGER, 2021, vol.~34, No~3, p.~272-282. ISSN~0896-0267. Available from: https://dx.doi.org/10.1007/s10548-021-00822-8.
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