J 2020

Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial

ANKER, S. D., J. BUTLER, G. FILIPPATOS, M. S. KHAN, J. P. FERREIRA et. al.

Základní údaje

Originální název

Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial

Autoři

ANKER, S. D. (garant), J. BUTLER, G. FILIPPATOS, M. S. KHAN, J. P. FERREIRA, E. BOCCHI, M. BOHM, Rocca H. P. BRUNNER-LA, D. J. CHOI, V. CHOPRA, E. CHUQUIURE, N. GIANNETTI, J. E. GOMEZ-MESA, S. JANSSENS, J. L. JANUZZI, J. R. GONZALEZ-JUANATEY, B. MERKELY, S. J. NICHOLLS, S. V. PERRONE, I. L. PINA, P. PONIKOWSKI, M. SENNI, M. F. SERONDE, D. SIM, Jindřich ŠPINAR (203 Česká republika, domácí), I. SQUIRE, S. TADDEI, H. TSUTSUI, S. VERMA, D. VINEREANU, J. ZHANG, W. JAMAL, S. SCHNAIDT, J. M. SCHNEE, M. BRUECKMANN, S. J. POCOCK, F. ZANNAD a M. PACKER

Vydání

European Journal of heart Failure, Hoboken, Wiley, 2020, 1388-9842

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Slovinsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 15.534

Kód RIV

RIV/00216224:14110/20:00118193

Organizační jednotka

Lékařská fakulta

UT WoS

000615960600025

Klíčová slova anglicky

Heart failure with preserved ejection fraction; Sodium glucose co transporter 2 inhibitors; Empagliflozin

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 29. 3. 2021 10:18, Mgr. Tereza Miškechová

Anotace

V originále

Aims EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares them with patients enrolled in prior HFpEF trials. Methods and results EMPEROR-Preserved is a phase III randomized, international, double-blind, parallel-group, placebo-controlled trial in which 5988 symptomatic HFpEF patients [left ventricular ejection fraction (LVEF) >40%] with and without type 2 diabetes mellitus (T2DM) have been enrolled. Patients were required to have elevated N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations (i.e. >300 pg/mL in patients without and >900 pg/mL in patients with atrial fibrillation) along with evidence of structural changes in the heart or documented history of heart failure hospitalization. Among patients enrolled from various regions (45% Europe, 11% Asia, 25% Latin America, 12% North America), the mean age was 72 +/- 9 years, 45% were women. Almost all patients had New York Heart Association class II or III symptoms (99.6%), and 23% had prior heart failure hospitalization within 12 months. Thirty-three percent of the patients had baseline LVEF of 41-50%. The mean LVEF (54 +/- 9%) was slightly lower while the median NT-proBNP [974 (499-1731) pg/mL] was higher compared with previous HFpEF trials. Presence of comorbidities such as diabetes (49%) and chronic kidney disease (50%) were common. The majority of the patients were on angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor-neprilysin inhibitors (80%) and beta-blockers (86%), and 37% of patients were on mineralocorticoid receptor antagonists. Conclusion When compared with prior trials in HFpEF, the EMPEROR-Preserved cohort has a somewhat higher burden of comorbidities, lower LVEF, higher median NT-proBNP and greater use of mineralocorticoid receptor antagonists at baseline. Results of the EMPEROR-Preserved trial will be available in 2021.