In silico study of pseudoprogression in glioblastoma:
collaboration of radiologists and radiation oncologists in the
estimation of extent of high dose RT region

J 2020

In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region

BELANOVÁ, Renata, Andrea ŠPRLÁKOVÁ-PUKOVÁ, Michal STANDARA, Eva JANŮ, Renata KOUKALOVÁ et. al.

Základní údaje

Originální název

In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region

Autoři

BELANOVÁ, Renata (203 Česká republika, domácí), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Česká republika, domácí), Michal STANDARA (203 Česká republika), Eva JANŮ (203 Česká republika, domácí), Renata KOUKALOVÁ (203 Česká republika, domácí), Jan KŘÍSTEK (203 Česká republika, domácí), Petr BURKOŇ (203 Česká republika, domácí), Ivana KOLOUŠKOVÁ (203 Česká republika, domácí), Tomáš PROCHÁZKA (203 Česká republika, domácí), Petr POSPÍŠIL (203 Česká republika, domácí), Arnab CHAKRAVARTI, Pavel ŠLAMPA (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, domácí) a Tomáš KAZDA (203 Česká republika, garant, domácí)

Vydání

Biomedical Papers, Olomouc, Palacky University, 2020, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.245

Kód RIV

RIV/00216224:14110/20:00118197

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2019.039

UT WoS

000595645600013

Klíčová slova anglicky

pseudoprogression; RANO; glioblastoma; radiotherapy; high-dose field

Štítky

14110216, 14110811, 14110812, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 2. 2021 12:30, Mgr. Tereza Miškechová

Anotace

V originále

Background and Aim. Oncologists play a vital role in the interpretation of radiographic results in glioblastoma patients. Molecular pathology and information on radiation treatment protocols among others are all important for accurate interpretation of radiology images. One important issue that may arise in interpreting such images is the phenomenon of tumor "pseudoprogression"; oncologists need to be able to distinguish this effect from true disease progression. Exact knowledge about the location of high-dose radiotherapy region is needed for valid determination of pseudoprogression according to RANO (Response Assessment in Neuro-Oncology) criteria in neurooncology. The aim of the present study was to evaluate the radiologists' understanding of a radiotherapy high-dose region in routine clinical practice since radiation oncologists do not always report 3-dimensional isodoses when ordering follow up imaging. Methods. Eight glioblastoma patients who underwent postresection radiotherapy were included in this study. Four radiologists worked with their pre-radiotherapy planning MR, however, they were blinded to RT target volumes which were defined by radiation oncologists according to current guidelines. The aim was to draw target volume for high dose RT fields (that is the region, where they would consider that there may be a pseudoprogression in future MRI scans). Many different indices describing structure differences were analyzed in comparison with original per-protocol RT target volumes. Results. The median volume for RT high dose field was 277 ccm (range 218 to 401 ccm) as defined per protocol by radiation oncologist and 87 ccm (range 32-338) as defined by radiologists (median difference of paired difference 31%, range 15-112%).The Median Dice index of similarity was 0.46 (range 0.14- 0.78), the median Hausdorff distance 25 mm. Conclusion. Continuing effort to improve education on specific procedures in RT and in radiology as well as automatic tools for exporting RT targets is needed in order to increase specificity and sensitivity in response evaluation.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV18-03-00398, projekt VaV

Název: Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Investor: Ministerstvo zdravotnictví ČR, Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

NV18-03-00469, projekt VaV

Název: Reakce neuronální populace hipokampu na stereotaktickou radioterapii extratemporálních mozkových metastáz: vliv na neurokognitivní funkce a zachování kvality života

Investor: Ministerstvo zdravotnictví ČR, Reakce neuronální populace hipokampu na stereotaktickou radioterapii extratemporálních mozkových metastáz: vliv na neurokognitivní funkce a zachování kvality života

Citovat

BELANOVÁ, Renata, Andrea ŠPRLÁKOVÁ-PUKOVÁ, Michal STANDARA, Eva JANŮ, Renata KOUKALOVÁ, Jan KŘÍSTEK, Petr BURKOŇ, Ivana KOLOUŠKOVÁ, Tomáš PROCHÁZKA, Petr POSPÍŠIL, Arnab CHAKRAVARTI, Pavel ŠLAMPA, Ondřej SLABÝ a Tomáš KAZDA. In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region. Biomedical Papers. Olomouc: Palacky University, 2020, roč. 164, č. 3, s. 307-313. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.039.

@article{1743640,
   author = {Belanová, Renata and ŠprlákováandPuková, Andrea and Standara, Michal and Janů, Eva and Koukalová, Renata and Křístek, Jan and Burkoň, Petr and Koloušková, Ivana and Procházka, Tomáš and Pospíšil, Petr and Chakravarti, Arnab and Šlampa, Pavel and Slabý, Ondřej and Kazda, Tomáš},
   article_location = {Olomouc},
   article_number = {3},
   doi = {http://dx.doi.org/10.5507/bp.2019.039},
   keywords = {pseudoprogression; RANO; glioblastoma; radiotherapy; high-dose field},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region},
   url = {https://biomed.papers.upol.cz/pdfs/bio/2020/03/13.pdf},
   volume = {164},
   year = {2020}
}

TY  - JOUR
ID  - 1743640
AU  - Belanová, Renata - Šprláková-Puková, Andrea - Standara, Michal - Janů, Eva - Koukalová, Renata - Křístek, Jan - Burkoň, Petr - Koloušková, Ivana - Procházka, Tomáš - Pospíšil, Petr - Chakravarti, Arnab - Šlampa, Pavel - Slabý, Ondřej - Kazda, Tomáš
PY  - 2020
TI  - In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region
JF  - Biomedical Papers
VL  - 164
IS  - 3
SP  - 307-313
EP  - 307-313
PB  - Palacky University
SN  - 12138118
KW  - pseudoprogression
KW  - RANO
KW  - glioblastoma
KW  - radiotherapy
KW  - high-dose field
UR  - https://biomed.papers.upol.cz/pdfs/bio/2020/03/13.pdf
L2  - https://biomed.papers.upol.cz/pdfs/bio/2020/03/13.pdf
N2  - Background and Aim. Oncologists play a vital role in the interpretation of radiographic results in glioblastoma patients. Molecular pathology and information on radiation treatment protocols among others are all important for accurate interpretation of radiology images. One important issue that may arise in interpreting such images is the phenomenon of tumor "pseudoprogression"; oncologists need to be able to distinguish this effect from true disease progression. Exact knowledge about the location of high-dose radiotherapy region is needed for valid determination of pseudoprogression according to RANO (Response Assessment in Neuro-Oncology) criteria in neurooncology. The aim of the present study was to evaluate the radiologists' understanding of a radiotherapy high-dose region in routine clinical practice since radiation oncologists do not always report 3-dimensional isodoses when ordering follow up imaging. Methods. Eight glioblastoma patients who underwent postresection radiotherapy were included in this study. Four radiologists worked with their pre-radiotherapy planning MR, however, they were blinded to RT target volumes which were defined by radiation oncologists according to current guidelines. The aim was to draw target volume for high dose RT fields (that is the region, where they would consider that there may be a pseudoprogression in future MRI scans). Many different indices describing structure differences were analyzed in comparison with original per-protocol RT target volumes. Results. The median volume for RT high dose field was 277 ccm (range 218 to 401 ccm) as defined per protocol by radiation oncologist and 87 ccm (range 32-338) as defined by radiologists (median difference of paired difference 31%, range 15-112%).The Median Dice index of similarity was 0.46 (range 0.14- 0.78), the median Hausdorff distance 25 mm. Conclusion. Continuing effort to improve education on specific procedures in RT and in radiology as well as automatic tools for exporting RT targets is needed in order to increase specificity and sensitivity in response evaluation.
ER  -

BELANOVÁ, Renata, Andrea ŠPRLÁKOVÁ-PUKOVÁ, Michal STANDARA, Eva JANŮ, Renata KOUKALOVÁ, Jan KŘÍSTEK, Petr BURKOŇ, Ivana KOLOUŠKOVÁ, Tomáš PROCHÁZKA, Petr POSPÍŠIL, Arnab CHAKRAVARTI, Pavel ŠLAMPA, Ondřej SLABÝ a Tomáš KAZDA. In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region. \textit{Biomedical Papers}. Olomouc: Palacky University, 2020, roč.~164, č.~3, s.~307-313. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.039.

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