Genoprotective activities of plant natural substances in cancer
and chemopreventive strategies in the context of 3P medicine

J 2020

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

KOKLESOVA, L., A. LISKOVA, M. SAMEC, T. QARADAKHI, A. ZULLI et. al.

Základní údaje

Originální název

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

Autoři

KOKLESOVA, L., A. LISKOVA, M. SAMEC, T. QARADAKHI, A. ZULLI, Karel ŠMEJKAL (203 Česká republika, domácí), K. KAJO, J. JAKUBIKOVA, P. BEHZADI, M. PEC, P. ZUBOR, K. BIRINGER, T.K. KWON, D. BUSSELBERG, G.R. SARRIA, F. A. GIORDANO, O. GOLUBNITSCHAJA a P. KUBATKA (garant)

Vydání

EPMA JOURNAL, CHAM, SPRINGER INTERNATIONAL PUBLISHING AG, 2020, 1878-5077

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.543

Kód RIV

RIV/00216224:14160/20:00118236

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1007/s13167-020-00210-5

UT WoS

000538040300009

Klíčová slova anglicky

Predictive Preventive Personalised Medicine (3PM; PPPM); Oncology; Tumour; Plant natural substances; Phytochemicals;

Štítky

rivok, ÚPL

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 2. 2021 14:09, Mgr. Hana Hurtová

Anotace

V originále

Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.

Citovat

KOKLESOVA, L., A. LISKOVA, M. SAMEC, T. QARADAKHI, A. ZULLI, Karel ŠMEJKAL, K. KAJO, J. JAKUBIKOVA, P. BEHZADI, M. PEC, P. ZUBOR, K. BIRINGER, T.K. KWON, D. BUSSELBERG, G.R. SARRIA, F. A. GIORDANO, O. GOLUBNITSCHAJA a P. KUBATKA. Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine. EPMA JOURNAL. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG, 2020, roč. 11, č. 2, s. 261-287. ISSN 1878-5077. Dostupné z: https://dx.doi.org/10.1007/s13167-020-00210-5.

@article{1745258,
   author = {Koklesova, L. and Liskova, A. and Samec, M. and Qaradakhi, T. and Zulli, A. and Šmejkal, Karel and Kajo, K. and Jakubikova, J. and Behzadi, P. and Pec, M. and Zubor, P. and Biringer, K. and Kwon, T.K. and Busselberg, D. and Sarria, G.R. and Giordano, F. A. and Golubnitschaja, O. and Kubatka, P.},
   article_location = {CHAM},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s13167-020-00210-5},
   keywords = {Predictive Preventive Personalised Medicine (3PM; PPPM); Oncology; Tumour; Plant natural substances; Phytochemicals;},
   language = {eng},
   issn = {1878-5077},
   journal = {EPMA JOURNAL},
   title = {Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine},
   url = {https://link.springer.com/article/10.1007/s13167-020-00210-5},
   volume = {11},
   year = {2020}
}

TY  - JOUR
ID  - 1745258
AU  - Koklesova, L. - Liskova, A. - Samec, M. - Qaradakhi, T. - Zulli, A. - Šmejkal, Karel - Kajo, K. - Jakubikova, J. - Behzadi, P. - Pec, M. - Zubor, P. - Biringer, K. - Kwon, T.K. - Busselberg, D. - Sarria, G.R. - Giordano, F. A. - Golubnitschaja, O. - Kubatka, P.
PY  - 2020
TI  - Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
JF  - EPMA JOURNAL
VL  - 11
IS  - 2
SP  - 261-287
EP  - 261-287
PB  - SPRINGER INTERNATIONAL PUBLISHING AG
SN  - 18785077
KW  - Predictive Preventive Personalised Medicine (3PM
KW  - PPPM)
KW  - Oncology
KW  - Tumour
KW  - Plant natural substances
KW  - Phytochemicals;
UR  - https://link.springer.com/article/10.1007/s13167-020-00210-5
N2  - Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
ER  -

KOKLESOVA, L., A. LISKOVA, M. SAMEC, T. QARADAKHI, A. ZULLI, Karel ŠMEJKAL, K. KAJO, J. JAKUBIKOVA, P. BEHZADI, M. PEC, P. ZUBOR, K. BIRINGER, T.K. KWON, D. BUSSELBERG, G.R. SARRIA, F. A. GIORDANO, O. GOLUBNITSCHAJA a P. KUBATKA. Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine. \textit{EPMA JOURNAL}. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG, 2020, roč.~11, č.~2, s.~261-287. ISSN~1878-5077. Dostupné z: https://dx.doi.org/10.1007/s13167-020-00210-5.

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