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@article{1745776,
author = {Treml, Jakub and Gazdová, Markéta and Šmejkal, Karel and Sudomova, M. and Kubatka, P. and Hassan, S. T. S.},
article_location = {Basel, Switzerland},
article_number = {2},
doi = {http://dx.doi.org/10.3390/v12020154},
keywords = {herpes simplex virus infection; bioactive natural products; drug resistance; drug development; antiherpetic drugs; preclinical and clinical studies; mechanisms of action},
language = {eng},
issn = {1999-4915},
journal = {Viruses-Basel},
title = {Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077281/},
volume = {12},
year = {2020}
}
TY - JOUR
ID - 1745776
AU - Treml, Jakub - Gazdová, Markéta - Šmejkal, Karel - Sudomova, M. - Kubatka, P. - Hassan, S. T. S.
PY - 2020
TI - Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development
JF - Viruses-Basel
VL - 12
IS - 2
SP - 1-42
EP - 1-42
PB - MDPI AG
SN - 19994915
KW - herpes simplex virus infection
KW - bioactive natural products
KW - drug resistance
KW - drug development
KW - antiherpetic drugs
KW - preclinical and clinical studies
KW - mechanisms of action
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077281/
N2 - Recently, the problem of viral infection, particularly the infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), has dramatically increased and caused a significant challenge to public health due to the rising problem of drug resistance. The antiherpetic drug resistance crisis has been attributed to the overuse of these medications, as well as the lack of new drug development by the pharmaceutical industry due to reduced economic inducements and challenging regulatory requirements. Therefore, the development of novel antiviral drugs against HSV infections would be a step forward in improving global combat against these infections. The incorporation of biologically active natural products into anti-HSV drug development at the clinical level has gained limited attention to date. Thus, the search for new drugs from natural products that could enter clinical practice with lessened resistance, less undesirable effects, and various mechanisms of action is greatly needed to break the barriers to novel antiherpetic drug development, which, in turn, will pave the road towards the efficient and safe treatment of HSV infections. In this review, we aim to provide an up-to-date overview of the recent advances in natural antiherpetic agents. Additionally, this paper covers a large scale of phenolic compounds, alkaloids, terpenoids, polysaccharides, peptides, and other miscellaneous compounds derived from various sources of natural origin (plants, marine organisms, microbial sources, lichen species, insects, and mushrooms) with promising activities against HSV infections; these are in vitro and in vivo studies. This work also highlights bioactive natural products that could be used as templates for the further development of anti-HSV drugs at both animal and clinical levels, along with the potential mechanisms by which these compounds induce anti-HSV properties. Future insights into the development of these molecules as safe and effective natural anti-HSV drugs are also debated.
ER -
TREML, Jakub, Markéta GAZDOVÁ, Karel ŠMEJKAL, M. SUDOMOVA, P. KUBATKA a S. T. S. HASSAN. Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development. \textit{Viruses-Basel}. Basel, Switzerland: MDPI AG, 2020, roč.~12, č.~2, s.~1-42. ISSN~1999-4915. Dostupné z: https://dx.doi.org/10.3390/v12020154.
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