Glucan particles as suitable carriers for the natural
anti-inflammatory compounds curcumin and diplacone - Evaluation
in an ex vivo model

J 2020

Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model

ROTREKL, Dominik, B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA et. al.

Základní údaje

Originální název

Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model

Autoři

ROTREKL, Dominik (203 Česká republika, domácí), B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA, P. SALAMUNOVA, Zuzana BAĎO (203 Česká republika), V. PROKOPEC, F. STEPANEK, J. HANUS a J. HOSEK

Vydání

International Journal of Pharmaceutics, AMSTERDAM, ELSEVIER SCIENCE BV, 2020, 0378-5173

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.875

Kód RIV

RIV/00216224:14160/20:00118256

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.1016/j.ijpharm.2020.119318

UT WoS

000535691300001

Klíčová slova anglicky

Glucan particles; Immunomodulatory effect; Inflammation; Blood immune cells; Curcumin; Diplacone

Štítky

rivok, ÚMF

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 3. 2021 12:50, Mgr. Hana Hurtová

Anotace

V originále

Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mainly of beta-1,3-D-glucan. Their indigestibility and relative stability in the gut combined with their immunomodulatory effects makes them promising carriers for such compounds. This study aimed to determine how curcumin and diplacone, either alone or incorporated in GPs, affect the immunomodulatory activity of the latter by assessing the respiratory burst response and the secretion of pro-inflammatory cytokines by primary porcine innate immune cells. Incorporating curcumin and diplacone into GPs by controlled evaporation of the organic solvent substantially reduced the respiratory burst response mediated by GPs. Incorporated curcumin in GPs also reduced GPs mediated secretion of IL-1 beta and TNF-alpha by innate immune cells. The obtained results indicate a potentially beneficial effect of the incorporation of curcumin or diplacone into GPs against inflammation.

Citovat

ROTREKL, Dominik, B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA, P. SALAMUNOVA, Zuzana BAĎO, V. PROKOPEC, F. STEPANEK, J. HANUS a J. HOSEK. Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model. International Journal of Pharmaceutics. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, roč. 582, č. 119318, s. 1-10. ISSN 0378-5173. Dostupné z: https://dx.doi.org/10.1016/j.ijpharm.2020.119318.

@article{1745919,
   author = {Rotrekl, Dominik and Devriendt, B. and Cox, E. and Kavanova, L. and Faldyna, M. and Salamunova, P. and Baďo, Zuzana and Prokopec, V. and Stepanek, F. and Hanus, J. and Hosek, J.},
   article_location = {AMSTERDAM},
   article_number = {119318},
   doi = {http://dx.doi.org/10.1016/j.ijpharm.2020.119318},
   keywords = {Glucan particles; Immunomodulatory effect; Inflammation; Blood immune cells; Curcumin; Diplacone},
   language = {eng},
   issn = {0378-5173},
   journal = {International Journal of Pharmaceutics},
   title = {Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model},
   url = {https://www.sciencedirect.com/science/article/pii/S0378517320303021},
   volume = {582},
   year = {2020}
}

TY  - JOUR
ID  - 1745919
AU  - Rotrekl, Dominik - Devriendt, B. - Cox, E. - Kavanova, L. - Faldyna, M. - Salamunova, P. - Baďo, Zuzana - Prokopec, V. - Stepanek, F. - Hanus, J. - Hosek, J.
PY  - 2020
TI  - Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model
JF  - International Journal of Pharmaceutics
VL  - 582
IS  - 119318
SP  - 1-10
EP  - 1-10
PB  - ELSEVIER SCIENCE BV
SN  - 03785173
KW  - Glucan particles
KW  - Immunomodulatory effect
KW  - Inflammation
KW  - Blood immune cells
KW  - Curcumin
KW  - Diplacone
UR  - https://www.sciencedirect.com/science/article/pii/S0378517320303021
N2  - Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mainly of beta-1,3-D-glucan. Their indigestibility and relative stability in the gut combined with their immunomodulatory effects makes them promising carriers for such compounds. This study aimed to determine how curcumin and diplacone, either alone or incorporated in GPs, affect the immunomodulatory activity of the latter by assessing the respiratory burst response and the secretion of pro-inflammatory cytokines by primary porcine innate immune cells. Incorporating curcumin and diplacone into GPs by controlled evaporation of the organic solvent substantially reduced the respiratory burst response mediated by GPs. Incorporated curcumin in GPs also reduced GPs mediated secretion of IL-1 beta and TNF-alpha by innate immune cells. The obtained results indicate a potentially beneficial effect of the incorporation of curcumin or diplacone into GPs against inflammation.
ER  -

ROTREKL, Dominik, B. DEVRIENDT, E. COX, L. KAVANOVA, M. FALDYNA, P. SALAMUNOVA, Zuzana BAĎO, V. PROKOPEC, F. STEPANEK, J. HANUS a J. HOSEK. Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model. \textit{International Journal of Pharmaceutics}. AMSTERDAM: ELSEVIER SCIENCE BV, 2020, roč.~582, č.~119318, s.~1-10. ISSN~0378-5173. Dostupné z: https://dx.doi.org/10.1016/j.ijpharm.2020.119318.

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