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@article{1746277,
author = {Forman, V. and Susanikova, I. and Kukurova, L. and Švajdlenka, Emil and Nagy, M. and Mucaji, P.},
article_location = {THOUSAND OAKS},
article_number = {3},
doi = {http://dx.doi.org/10.1177/1934578X20912868},
keywords = {Cornus mas; Cornus kousa; aldose reductase; diabetes mellitus; lipotoxicity; NIH-3T3 cell line},
language = {eng},
issn = {1934-578X},
journal = {Natural Product Communications},
title = {Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity},
url = {https://journals.sagepub.com/doi/10.1177/1934578X20912868},
volume = {15},
year = {2020}
}
TY - JOUR
ID - 1746277
AU - Forman, V. - Susanikova, I. - Kukurova, L. - Švajdlenka, Emil - Nagy, M. - Mucaji, P.
PY - 2020
TI - Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity
JF - Natural Product Communications
VL - 15
IS - 3
SP - 1-7
EP - 1-7
PB - SAGE PUBLICATIONS INC
SN - 1934578X
KW - Cornus mas
KW - Cornus kousa
KW - aldose reductase
KW - diabetes mellitus
KW - lipotoxicity
KW - NIH-3T3 cell line
UR - https://journals.sagepub.com/doi/10.1177/1934578X20912868
N2 - Aldose reductase inhibitors are considered to be potential therapeutic agents for chronic diabetic complications. Diabetes mellitus can be accompanied by elevated blood levels of free fatty acids, which can cause lipotoxicity. Herbal extracts and their constituents are promising agents which have the potential for alleviating these complications. Our study was focused on the influence on these effects by flower infusions from Comus mar L. and Cornus kousa F.Buerger ex Hance. Initially, phenolic compounds were quantified in the dried flowers. Next, we studied the ability of flower infusions from both plants to inhibit aldose reductase in vitro, the protective role in the cell model of lipotoxicity, and the cytotoxic action on fibroblast cell line NIH-3T3 by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Both species are rich in phenolics; C. kousa flowers contain slightly higher amounts of phenolic acids (20.8%) and flavonoids (56.1%) than C. mas (20.2%) and (47.4%), respectively. Both extracts showed effective inhibition, expressed as half-maximal inhibitory concentration (IC50) (the concentration of inhibitor required to exhibit 50% inhibition of the enzyme reaction), of aldose reductase in non-toxic low concentrations (IC50 = 3.06 mu g/mL for C. mas and IC50 = 2.49 mu g/mL for C. kousa, respectively). In contrast, these concentrations of both extracts had almost no effects in the lipotoxicity cell model. To our knowledge, this study is the first report on C. mar and C. kousa flowers' aldose reductase inhibitory activity and influence upon lipotoxicity.
ER -
FORMAN, V., I. SUSANIKOVA, L. KUKUROVA, Emil ŠVAJDLENKA, M. NAGY and P. MUCAJI. Flower Infusions From Cornus mas and Cornus kousa Inhibit Aldose Reductase Enzyme, Without Any Effects on Lipotoxicity. \textit{Natural Product Communications}. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2020, vol.~15, No~3, p.~1-7. ISSN~1934-578X. Available from: https://dx.doi.org/10.1177/1934578X20912868.
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