| JOHARD, H., A. OMELYANENKO, G. FEI, M. ZILBERTER, Z. DAVE, R. ABU-YOUSSEF, L. SCHMIDT, A. HARISANKAR, C.T. VINCENT, J. WALFRIDSSON, S. NELANDER, T. HARKANY, K. BLOMGREN a Michael ANDÄNG. HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment. MOLECULAR CANCER RESEARCH. PHILADELPHIA: AMER ASSOC CANCER RESEARCH, 2020, roč. 18, č. 10, s. 1522-1533. ISSN 1541-7786. Dostupné z: https://dx.doi.org/10.1158/1541-7786.MCR-20-0292. |
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@article{1748362,
author = {Johard, H. and Omelyanenko, A. and Fei, G. and Zilberter, M. and Dave, Z. and AbuandYoussef, R. and Schmidt, L. and Harisankar, A. and Vincent, C.T. and Walfridsson, J. and Nelander, S. and Harkany, T. and Blomgren, K. and Andäng, Michael},
article_location = {PHILADELPHIA},
article_number = {10},
doi = {http://dx.doi.org/10.1158/1541-7786.MCR-20-0292},
keywords = {LONG-TERM; ADULT; NEUROGENESIS; CYCLE; IRRADIATION; RECEPTOR; PURIFICATION; HIPPOCAMPUS; DYNAMICS; CULTURE},
language = {eng},
issn = {1541-7786},
journal = {MOLECULAR CANCER RESEARCH},
title = {HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment},
url = {https://mcr.aacrjournals.org/content/18/10/1522},
volume = {18},
year = {2020}
}
TY - JOUR
ID - 1748362
AU - Johard, H. - Omelyanenko, A. - Fei, G. - Zilberter, M. - Dave, Z. - Abu-Youssef, R. - Schmidt, L. - Harisankar, A. - Vincent, C.T. - Walfridsson, J. - Nelander, S. - Harkany, T. - Blomgren, K. - Andäng, Michael
PY - 2020
TI - HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment
JF - MOLECULAR CANCER RESEARCH
VL - 18
IS - 10
SP - 1522-1533
EP - 1522-1533
PB - AMER ASSOC CANCER RESEARCH
SN - 15417786
KW - LONG-TERM
KW - ADULT
KW - NEUROGENESIS
KW - CYCLE
KW - IRRADIATION
KW - RECEPTOR
KW - PURIFICATION
KW - HIPPOCAMPUS
KW - DYNAMICS
KW - CULTURE
UR - https://mcr.aacrjournals.org/content/18/10/1522
N2 - Children suffering from neurologic cancers undergoing chemotherapy and radiotherapy are at high risk of reduced neurocognitive abilities likely via damage to proliferating neural stem cells (NSC). Therefore, strategies to protect NSCs are needed. We argue that induced cell-cycle arrest/quiescence in NSCs during cancer treatment can represent such a strategy. Here, we show that hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are dynamically expressed over the cell cycle in NSCs, depolarize the membrane potential, underlie spontaneous calcium oscillations and are required to maintain NSCs in the actively proliferating pool. Hyperpolarizing pharmacologic inhibition of HCN channels during exposure to ionizing radiation protects NSCs cells in neurogenic brain regions of young mice. In contrast, brain tumor-initiating cells, which also express HCN channels, remain proliferative during HCN inhibition.
ER -
JOHARD, H., A. OMELYANENKO, G. FEI, M. ZILBERTER, Z. DAVE, R. ABU-YOUSSEF, L. SCHMIDT, A. HARISANKAR, C.T. VINCENT, J. WALFRIDSSON, S. NELANDER, T. HARKANY, K. BLOMGREN a Michael ANDÄNG. HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment. \textit{MOLECULAR CANCER RESEARCH}. PHILADELPHIA: AMER ASSOC CANCER RESEARCH, 2020, roč.~18, č.~10, s.~1522-1533. ISSN~1541-7786. Dostupné z: https://dx.doi.org/10.1158/1541-7786.MCR-20-0292.
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