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@article{1751479, author = {Raxwal, Vivek Kumar and Ghosh, S. and Singh, S. and KatiyarandAgarwal, S. and Goel, S. and Jagannath, A. and Kumar, A. and Scaria, V. and Agarwal, M.}, article_location = {Oxford}, article_number = {17}, doi = {http://dx.doi.org/10.1093/jxb/eraa286}, keywords = {Abiotic stress; Arabidopsis; chromatin landscape; DNase-seq; FAIRE-seq; open chromatin; transcription}, language = {eng}, issn = {0022-0957}, journal = {Journal of Experimental Botany}, title = {Abiotic stress-mediated modulation of the chromatin landscape in Arabidopsis thaliana}, url = {https://academic.oup.com/jxb/article/71/17/5280/5856113}, volume = {71}, year = {2020} }
TY - JOUR ID - 1751479 AU - Raxwal, Vivek Kumar - Ghosh, S. - Singh, S. - Katiyar-Agarwal, S. - Goel, S. - Jagannath, A. - Kumar, A. - Scaria, V. - Agarwal, M. PY - 2020 TI - Abiotic stress-mediated modulation of the chromatin landscape in Arabidopsis thaliana JF - Journal of Experimental Botany VL - 71 IS - 17 SP - 5280-5293 EP - 5280-5293 PB - OXFORD UNIV PRESS SN - 00220957 KW - Abiotic stress KW - Arabidopsis KW - chromatin landscape KW - DNase-seq KW - FAIRE-seq KW - open chromatin KW - transcription UR - https://academic.oup.com/jxb/article/71/17/5280/5856113 N2 - Limited information is available on abiotic stress-mediated alterations of chromatin conformation influencing gene expression in plants. In order to characterize the effect of abiotic stresses on changes in chromatin conformation, we employed FAIRE-seq (formaldehyde-assisted isolation of regulatory element sequencing) and DNase-seq to isolate accessible regions of chromatin from Arabidopsis thaliana seedlings exposed to either heat, cold, salt, or drought stress. Approximately 25% of regions in the Arabidopsis genome were captured as open chromatin, the majority of which included promoters and exons. A large proportion of chromatin regions apparently did not change their conformation in response to any of the four stresses. Digital footprints present within these regions had differential enrichment of motifs for binding of 43 different transcription factors. Further, in contrast to drought and salt stress, both high and low temperature treatments resulted in increased accessibility of the chromatin. Also, pseudogenes attained increased chromatin accessibility in response to cold and drought stresses. The highly accessible and inaccessible chromatin regions of seedlings exposed to drought stress correlated with the Ser/Thr protein kinases (MLK1 and MLK2)-mediated reduction and increase in H3 phosphorylation (H3T3Ph), respectively. The presented results provide a deeper understanding of abiotic stress-mediated chromatin modulation in plants. ER -
RAXWAL, Vivek Kumar, S. GHOSH, S. SINGH, S. KATIYAR-AGARWAL, S. GOEL, A. JAGANNATH, A. KUMAR, V. SCARIA a M. AGARWAL. Abiotic stress-mediated modulation of the chromatin landscape in Arabidopsis thaliana. \textit{Journal of Experimental Botany}. Oxford: OXFORD UNIV PRESS, 2020, roč.~71, č.~17, s.~5280-5293. ISSN~0022-0957. Dostupné z: https://dx.doi.org/10.1093/jxb/eraa286.
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