| HULSTAERT, E., A. MORLION, F.A. COBOS, K. VERNIERS, J. NUYTENS, E. VANDEN EYNDE, N. YIGIT, J. ANCKAERT, A. GEERTS, P. HINDRYCKX, P. JACQUES, G. BRUSSELLE, K.R. BRACKE, T. MAES, T. MALFAIT, T. DERVEAUX, V. NINCLAUS, C. VAN CAUWENBERGH, K. ROELENS, E. ROETS, D. HEMELSOET, K. TILLEMAN, L. BROCHEZ, S. KUERSTEN, L.M. SIMON, S. KARG, A. KAUTZKY-WILLERS, M. LEUTNER, C. NOHAMMER, Ondřej SLABÝ, R.W. PRINS, J. KOSTER, S. LEFEVER, G.P. SCHROTH, J. VANDESOMPELE a P. MESTDAGH. Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas. Cell Reports. CAMBRIDGE: Cell Press, 2020, roč. 33, č. 13, s. 108552-108570. ISSN 2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2020.108552. |
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@article{1752480,
author = {Hulstaert, E. and Morlion, A. and Cobos, F.A. and Verniers, K. and Nuytens, J. and Vanden Eynde, E. and Yigit, N. and Anckaert, J. and Geerts, A. and Hindryckx, P. and Jacques, P. and Brusselle, G. and Bracke, K.R. and Maes, T. and Malfait, T. and Derveaux, T. and Ninclaus, V. and Van Cauwenbergh, C. and Roelens, K. and Roets, E. and Hemelsoet, D. and Tilleman, K. and Brochez, L. and Kuersten, S. and Simon, L.M. and Karg, S. and KautzkyandWillers, A. and Leutner, M. and Nohammer, C. and Slabý, Ondřej and Prins, R.W. and Koster, J. and Lefever, S. and Schroth, G.P. and Vandesompele, J. and Mestdagh, P.},
article_location = {CAMBRIDGE},
article_number = {13},
doi = {http://dx.doi.org/10.1016/j.celrep.2020.108552},
keywords = {MESSENGER-RNA; CIRCULAR RNA; EXPRESSION; LANDSCAPE; MICRORNA; BIOMARKERS},
language = {eng},
issn = {2211-1247},
journal = {Cell Reports},
title = {Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas},
url = {https://www.sciencedirect.com/science/article/pii/S2211124720315412?via%3Dihub},
volume = {33},
year = {2020}
}
TY - JOUR
ID - 1752480
AU - Hulstaert, E. - Morlion, A. - Cobos, F.A. - Verniers, K. - Nuytens, J. - Vanden Eynde, E. - Yigit, N. - Anckaert, J. - Geerts, A. - Hindryckx, P. - Jacques, P. - Brusselle, G. - Bracke, K.R. - Maes, T. - Malfait, T. - Derveaux, T. - Ninclaus, V. - Van Cauwenbergh, C. - Roelens, K. - Roets, E. - Hemelsoet, D. - Tilleman, K. - Brochez, L. - Kuersten, S. - Simon, L.M. - Karg, S. - Kautzky-Willers, A. - Leutner, M. - Nohammer, C. - Slabý, Ondřej - Prins, R.W. - Koster, J. - Lefever, S. - Schroth, G.P. - Vandesompele, J. - Mestdagh, P.
PY - 2020
TI - Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas
JF - Cell Reports
VL - 33
IS - 13
SP - 108552
EP - 108552
PB - Cell Press
SN - 22111247
KW - MESSENGER-RNA
KW - CIRCULAR RNA
KW - EXPRESSION
KW - LANDSCAPE
KW - MICRORNA
KW - BIOMARKERS
UR - https://www.sciencedirect.com/science/article/pii/S2211124720315412?via%3Dihub
N2 - Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids. By means of synthetic spike-in controls, we compare RNA content across biofluids, revealing a 10,000-fold difference in concentration. The circular RNA fraction is increased in most biofluids compared to tissues. Each biofluid transcriptome is enriched for RNA molecules derived from specific tissues and cell types. Our atlas enables an informed selection of the most relevant biofluid to monitor particular diseases. To verify the biomarker potential in these biofluids, four validation cohorts representing a broad spectrum of diseases were profiled, revealing numerous differential RNAs between case and control subjects. Spike-normalized data are publicly available in the R2 web portal for further exploration.
ER -
HULSTAERT, E., A. MORLION, F.A. COBOS, K. VERNIERS, J. NUYTENS, E. VANDEN EYNDE, N. YIGIT, J. ANCKAERT, A. GEERTS, P. HINDRYCKX, P. JACQUES, G. BRUSSELLE, K.R. BRACKE, T. MAES, T. MALFAIT, T. DERVEAUX, V. NINCLAUS, C. VAN CAUWENBERGH, K. ROELENS, E. ROETS, D. HEMELSOET, K. TILLEMAN, L. BROCHEZ, S. KUERSTEN, L.M. SIMON, S. KARG, A. KAUTZKY-WILLERS, M. LEUTNER, C. NOHAMMER, Ondřej SLABÝ, R.W. PRINS, J. KOSTER, S. LEFEVER, G.P. SCHROTH, J. VANDESOMPELE a P. MESTDAGH. Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas. \textit{Cell Reports}. CAMBRIDGE: Cell Press, 2020, roč.~33, č.~13, s.~108552-108570. ISSN~2211-1247. Dostupné z: https://dx.doi.org/10.1016/j.celrep.2020.108552.
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