Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1753044,
author = {Sinigaglia, Ketty and Melicherová, Janka and Stejskal, Stanislav and Keegan, Liam and O'Connell, Mary Anne},
booktitle = {CEITEC PhD Conference},
keywords = {ADAR1},
language = {eng},
title = {Elucidating the Biological Role of ADAR1 in the Innate immunity Response},
url = {https://www.ceitec.eu/abstract-book-final-docx-pdf/f36324},
year = {2020}
}
TY - CONF
ID - 1753044
AU - Sinigaglia, Ketty - Melicherová, Janka - Stejskal, Stanislav - Keegan, Liam - O'Connell, Mary Anne
PY - 2020
TI - Elucidating the Biological Role of ADAR1 in the Innate immunity Response
KW - ADAR1
UR - https://www.ceitec.eu/abstract-book-final-docx-pdf/f36324
N2 - One of the most common and best studied type of RNA editing in higher eukaryotes is the hydrolytic deamination of adenosine to inosine within doublestranded RNAs (dsRNAs), by the enzyme family adenosine deaminases acting on RNA (ADAR). As inosine base-pairs with cytidine (C), it is translated and reversetranscribed as a guanosine (G), changing the sequence of an RNA. ADAR1 edits cellular dsRNA to prevent aberrant activation of cytoplasmic antiviral dsRNA sensors and missense mutations, that change ADAR1 residues and reduce RNA editing activity, cause Aicardi-Goutieres Syndrome, a childhood encephalitis and interferonopathy. ADAR2 is most highly expressed in brain and it is primarily required for site-specific editing of glutamate receptor transcripts. Mutations in ADAR2 could contribute to excitability syndromes such as epilepsy, to seizures and to diseases involving neuronal plasticity defects.
ER -
SINIGAGLIA, Ketty, Janka MELICHEROVÁ, Stanislav STEJSKAL, Liam KEEGAN a Mary Anne O'CONNELL. Elucidating the Biological Role of ADAR1 in the Innate immunity Response. In \textit{CEITEC PhD Conference}. 2020.
|
