Use of the Crustacean Artemia franciscana for Alternative Biotests

DVORAK, Petr, Katarina BENOVA, Michal ZDARSKY, Zbynek SKLENAR a Alena HAVELKOVÁ. Use of the Crustacean Artemia franciscana for Alternative Biotests. Acta veterinaria (Brno). Brno: VFU Brno, ČR, 2010, roč. 79, s. "S47"-"S53". ISSN 0001-7213. Dostupné z: https://dx.doi.org/10.2754/avb201079S9S047.

Základní údaje

Originální název

Use of the Crustacean Artemia franciscana for Alternative Biotests

Autoři

DVORAK, Petr, Katarina BENOVA, Michal ZDARSKY, Zbynek SKLENAR a Alena HAVELKOVÁ

Vydání

Acta veterinaria (Brno), Brno, VFU Brno, ČR, 2010, 0001-7213

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Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 0.534

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.2754/avb201079S9S047

UT WoS

000282195800008

Příznaky

Recenzováno

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Anotace

V originále

Use of the crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well, or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta (89)Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyclin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates.