Different Chronotherapy Protocols Applied to Blood Pressure

D 2017

Different Chronotherapy Protocols Applied to Blood Pressure

CORNELISSEN, G., Y. WATANABE, Jarmila SIEGELOVÁ, Jiří DUŠEK, Alena HAVELKOVÁ et. al.

Základní údaje

Originální název

Different Chronotherapy Protocols Applied to Blood Pressure

Autoři

CORNELISSEN, G., Y. WATANABE, Jarmila SIEGELOVÁ, Jiří DUŠEK, Alena HAVELKOVÁ, Leona DUNKLEROVÁ, C. TURNER, L. BEATY a K. OTSUKA

Vydání

Brno, Noninvasive methods in cardiology 2017, od s. 69-82, 2017

Nakladatel

Masarykova univerzita

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Lékařská fakulta

ISBN

978-80-210-8794-1

Změněno: 26. 3. 2021 14:51, Mgr. Tereza Miškechová

Anotace

V originále

Blood pressure serves both as a marker variable and as a gauge of the response to timed treatment (chronotherapy). The relative merits of several transverse and longitudinal chronotherapy designs are reviewed herein, from small studies on groups and N-of-6 pilot studies to larger clinical trials. Some chronotherapy designs are aimed at optimal results for the average patient in a given target population, while others aim at personalized chronotherapy, where each patient in the study is considered as an N-of-1 pilot. All chronotherapy trials considered herein relied on around-the-clock blood pressure measurements obtained automatically to determine optimal treatment times. Because anti-hypertensive medications can affect the circadian amplitude in addition to the rhythm-adjusted average (MESOR), treatment effects should be assessed on all characteristics of the circadian blood pressure rhythm. Because abnormal blood pressure and heart rate variability also relates to cardiovascular disease risk, anti-hypertensive treatment should target not only the lowering of blood pressure, but also the restoration of an acceptable circadian variation in blood pressure. Methods to analyze individual blood pressure records makes it now feasible to determine personalized optimal treatment times. Outcome studies remain to be performed to assess the gain to be obtained from personalized chronotherapy in terms of an actual decrease in adverse cardiovascular events.

Citovat

CORNELISSEN, G., Y. WATANABE, Jarmila SIEGELOVÁ, Jiří DUŠEK, Alena HAVELKOVÁ, Leona DUNKLEROVÁ, C. TURNER, L. BEATY a K. OTSUKA. Different Chronotherapy Protocols Applied to Blood Pressure. In Cornélissen G., Siegelová J., Dobšák P. Noninvasive methods in cardiology 2017. Brno: Masarykova univerzita, 2017, s. 69-82. ISBN 978-80-210-8794-1.

@inproceedings{1755705,
   author = {Cornelissen, G. and Watanabe, Y. and Siegelová, Jarmila and Dušek, Jiří and Havelková, Alena and Dunklerová, Leona and Turner, C. and Beaty, L. and Otsuka, K.},
   address = {Brno},
   booktitle = {Noninvasive methods in cardiology 2017},
   editor = {Cornélissen G., Siegelová J., Dobšák P.},
   language = {eng},
   location = {Brno},
   isbn = {978-80-210-8794-1},
   pages = {69-82},
   publisher = {Masarykova univerzita},
   title = {Different Chronotherapy Protocols Applied to Blood Pressure},
   url = {https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/noninvasive_methods_in_cardiology_2017.pdf},
   year = {2017}
}

TY  - JOUR
ID  - 1755705
AU  - Cornelissen, G. - Watanabe, Y. - Siegelová, Jarmila - Dušek, Jiří - Havelková, Alena - Dunklerová, Leona - Turner, C. - Beaty, L. - Otsuka, K.
PY  - 2017
TI  - Different Chronotherapy Protocols Applied to Blood Pressure
PB  - Masarykova univerzita
CY  - Brno
SN  - 9788021087941
UR  - https://is.muni.cz/do/med/noninvasive_methods_in_cardiology/noninvasive_methods_in_cardiology_2017.pdf
N2  - Blood pressure serves both as a marker variable and as a gauge of the response to timed treatment (chronotherapy). The relative merits of several transverse and longitudinal chronotherapy designs are reviewed herein, from small studies on groups and N-of-6 pilot studies to larger clinical trials. Some chronotherapy designs are aimed at optimal results for the average patient in a given target population, while others aim at personalized chronotherapy, where each patient in the study is considered as an N-of-1 pilot. All chronotherapy trials considered herein relied on around-the-clock blood pressure measurements obtained automatically to determine optimal treatment times. Because anti-hypertensive medications can affect the circadian amplitude in addition to the rhythm-adjusted average (MESOR), treatment effects should be assessed on all characteristics of the circadian blood pressure rhythm. Because abnormal blood pressure and heart rate variability also relates to cardiovascular disease risk, anti-hypertensive treatment should target not only the lowering of blood pressure, but also the restoration of an acceptable circadian variation in blood pressure. Methods to analyze individual blood pressure records makes it now feasible to determine personalized optimal treatment times. Outcome studies remain to be performed to assess the gain to be obtained from personalized chronotherapy in terms of an actual decrease in adverse cardiovascular events.
ER  -

CORNELISSEN, G., Y. WATANABE, Jarmila SIEGELOVÁ, Jiří DUŠEK, Alena HAVELKOVÁ, Leona DUNKLEROVÁ, C. TURNER, L. BEATY a K. OTSUKA. Different Chronotherapy Protocols Applied to Blood Pressure. In Cornélissen G., Siegelová J., Dobšák P. \textit{Noninvasive methods in cardiology 2017}. Brno: Masarykova univerzita, 2017, s.~69-82. ISBN~978-80-210-8794-1.

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