| SKOPALOVÁ, Kateřina, Katarzyna Anna RADASZKIEWICZ, Věra KAŠPÁRKOVÁ, Jaroslav STEJSKAL, Patrycja BOBER, Ita JUNKAR, Miran MOZETIC, Zdenka CAPÁKOVÁ, Marián LEHOCKÝ, Martina KAŠPAROVÁ, Jiří PACHERNÍK a Petr HUMPOLÍČEK. Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis. International Journal of Molecular Sciences. Basel: MDPI, 2021, roč. 22, č. 2, s. "501", 17 s. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms22020501. |
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@article{1756256,
author = {Skopalová, Kateřina and Radaszkiewicz, Katarzyna Anna and Kašpárková, Věra and Stejskal, Jaroslav and Bober, Patrycja and Junkar, Ita and Mozetic, Miran and Capáková, Zdenka and Lehocký, Marián and Kašparová, Martina and Pacherník, Jiří and Humpolíček, Petr},
article_location = {Basel},
article_number = {2},
doi = {http://dx.doi.org/10.3390/ijms22020501},
keywords = {conducting polymer; polypyrrole; biocompatibility; neurogenesis; stem cells},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis},
url = {https://doi.org/10.3390/ijms22020501},
volume = {22},
year = {2021}
}
TY - JOUR
ID - 1756256
AU - Skopalová, Kateřina - Radaszkiewicz, Katarzyna Anna - Kašpárková, Věra - Stejskal, Jaroslav - Bober, Patrycja - Junkar, Ita - Mozetic, Miran - Capáková, Zdenka - Lehocký, Marián - Kašparová, Martina - Pacherník, Jiří - Humpolíček, Petr
PY - 2021
TI - Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis
JF - International Journal of Molecular Sciences
VL - 22
IS - 2
SP - "501"
EP - "501"
PB - MDPI
SN - 14220067
KW - conducting polymer
KW - polypyrrole
KW - biocompatibility
KW - neurogenesis
KW - stem cells
UR - https://doi.org/10.3390/ijms22020501
N2 - The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
ER -
SKOPALOVÁ, Kateřina, Katarzyna Anna RADASZKIEWICZ, Věra KAŠPÁRKOVÁ, Jaroslav STEJSKAL, Patrycja BOBER, Ita JUNKAR, Miran MOZETIC, Zdenka CAPÁKOVÁ, Marián LEHOCKÝ, Martina KAŠPAROVÁ, Jiří PACHERNÍK a Petr HUMPOLÍČEK. Modulation of Differentiation of Embryonic Stem Cells by Polypyrrole: The Impact on Neurogenesis. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2021, roč.~22, č.~2, s.~''501'', 17 s. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms22020501.
|
