No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver ...

@article{1757098,
   author = {Anandan, Sampath Kumar and Albrecht, Tomáš and Kauzál, Ondřej and Tomášek, Oldřich},
   article_location = {Lausanne},
   article_number = {March},
   doi = {http://dx.doi.org/10.3389/fcell.2021.638501},
   keywords = {membrane pacemaker hypothesis; life-history trade-offs; pace-of-life syndromes; membrane unsaturation; evolution of longevity; ageing; aging; senescence},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver Fatty Acid Composition in Birds},
   url = {https://doi.org/10.3389/fcell.2021.638501},
   volume = {9},
   year = {2021}
}

TY  - JOUR
ID  - 1757098
AU  - Anandan, Sampath Kumar - Albrecht, Tomáš - Kauzál, Ondřej - Tomášek, Oldřich
PY  - 2021
TI  - No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver Fatty Acid Composition in Birds
JF  - Frontiers in Cell and Developmental Biology
VL  - 9
IS  - March
SP  - "638501"
EP  - "638501"
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - membrane pacemaker hypothesis
KW  - life-history trade-offs
KW  - pace-of-life syndromes
KW  - membrane unsaturation
KW  - evolution of longevity
KW  - ageing
KW  - aging
KW  - senescence
UR  - https://doi.org/10.3389/fcell.2021.638501
N2  - The fatty acid composition of biological membranes has been hypothesised to be a key molecular adaptation associated with the evolution of metabolic rates, ageing, and life span – the basis of the membrane pacemaker hypothesis (MPH). MPH proposes that highly unsaturated membranes enhance cellular metabolic processes while being more prone to oxidative damage, thereby increasing the rates of metabolism and ageing. MPH could, therefore, provide a mechanistic explanation for trade-offs between longevity, fecundity, and metabolic rates, predicting that short-lived species with fast metabolic rates and higher fecundity would have greater levels of membrane unsaturation. However, previous comparative studies testing MPH provide mixed evidence regarding the direction of covariation between fatty acid unsaturation and life span or metabolic rate. Moreover, some empirical studies suggest that an n-3/n-6 PUFA ratio or the fatty acid chain length, rather than the overall unsaturation, could be the key traits coevolving with life span. In this study, we tested the coevolution of liver fatty acid composition with maximum life span, annual fecundity, and basal metabolic rate (BMR), using a recently published data set comprising liver fatty acid composition of 106 avian species. While statistically controlling for the confounding effects of body mass and phylogeny, we found no support for long life span evolving with low fatty acid unsaturation and only very weak support for fatty acid unsaturation acting as a pacemaker of BMR. Moreover, our analysis provided no evidence for the previously reported links between life span and n-3 PUFA/total PUFA or MUFA proportion. Our results rather suggest that long life span evolves with long-chain fatty acids irrespective of their degree of unsaturation as life span was positively associated with at least one long-chain fatty acid of each type (i.e., SFA, MUFA, n-6 PUFA, and n-3 PUFA). Importantly, maximum life span, annual fecundity, and BMR were associated with different fatty acids or fatty acid indices, indicating that longevity, fecundity, and BMR coevolve with different aspects of fatty acid composition. Therefore, in addition to posing significant challenges to MPH, our results imply that fatty acid composition does not pose an evolutionary constraint underpinning life-history trade-offs at the molecular level.
ER  - 

ANANDAN, Sampath Kumar, Tomáš ALBRECHT, Ondřej KAUZÁL a Oldřich TOMÁŠEK. No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver Fatty Acid Composition in Birds. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2021, roč.~9, March, s.~''638501'', 12 s. ISSN~2296-634X. Dostupné z: https://dx.doi.org/10.3389/fcell.2021.638501.