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@article{1758050,
author = {Bonczek, Ondrej and Krejci, Premysl and Izakovičová Hollá, Lydie and Černochová, Pavlína and Kiss, Igor and Vojtesek, Borivoj},
article_location = {Hoboken},
article_number = {4},
doi = {http://dx.doi.org/10.1111/cge.13892},
keywords = {cancer; genetic variants; hypodontia; odontogenesis; oligodontia; predictive marker; WNT pathway},
language = {eng},
issn = {0009-9163},
journal = {Clinical Genetics},
title = {Tooth agenesis: What do we know and is there a connection to cancer?},
url = {https://onlinelibrary.wiley.com/doi/10.1111/cge.13892},
volume = {99},
year = {2021}
}
TY - JOUR
ID - 1758050
AU - Bonczek, Ondrej - Krejci, Premysl - Izakovičová Hollá, Lydie - Černochová, Pavlína - Kiss, Igor - Vojtesek, Borivoj
PY - 2021
TI - Tooth agenesis: What do we know and is there a connection to cancer?
JF - Clinical Genetics
VL - 99
IS - 4
SP - 493-502
EP - 493-502
PB - Wiley
SN - 00099163
KW - cancer
KW - genetic variants
KW - hypodontia
KW - odontogenesis
KW - oligodontia
KW - predictive marker
KW - WNT pathway
UR - https://onlinelibrary.wiley.com/doi/10.1111/cge.13892
N2 - Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3, and components and regulators of WNT signaling WNT10B, LRP6, DKK, and KREMEN1 are at the forefront of interest. Due to the interconnectedness of the signaling pathways of carcinogenesis and odontogenesis, tooth agenesis could be a suitable marker for early detection of cancer predisposition. Variants in genes associated with tooth agenesis could serve as prognostic or therapeutic targets in cancer. This review aims to summarize existing knowledge of development and clinical genetics of teeth. Concurrently, the review proposes possible approaches for future research in this area, with particular attention to roles in monitoring, early diagnosis and therapy of tumors associated with defective tooth development.
ER -
BONCZEK, Ondrej, Premysl KREJCI, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, Igor KISS a Borivoj VOJTESEK. Tooth agenesis: What do we know and is there a connection to cancer? \textit{Clinical Genetics}. Hoboken: Wiley, 2021, roč.~99, č.~4, s.~493-502. ISSN~0009-9163. Dostupné z: https://dx.doi.org/10.1111/cge.13892.
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