Tooth agenesis: What do we know and is there a connection to
cancer?

J 2021

Tooth agenesis: What do we know and is there a connection to cancer?

BONCZEK, Ondrej, Premysl KREJCI, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, Igor KISS et. al.

Základní údaje

Originální název

Tooth agenesis: What do we know and is there a connection to cancer?

Autoři

BONCZEK, Ondrej (203 Česká republika, garant), Premysl KREJCI (203 Česká republika), Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí), Pavlína ČERNOCHOVÁ (203 Česká republika, domácí), Igor KISS (203 Česká republika) a Borivoj VOJTESEK (203 Česká republika)

Vydání

Clinical Genetics, Hoboken, Wiley, 2021, 0009-9163

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.296

Kód RIV

RIV/00216224:14110/21:00121356

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/cge.13892

UT WoS

000618548500001

Klíčová slova anglicky

cancer; genetic variants; hypodontia; odontogenesis; oligodontia; predictive marker; WNT pathway

Štítky

14110130, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2021 10:50, Mgr. Tereza Miškechová

Anotace

V originále

Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3, and components and regulators of WNT signaling WNT10B, LRP6, DKK, and KREMEN1 are at the forefront of interest. Due to the interconnectedness of the signaling pathways of carcinogenesis and odontogenesis, tooth agenesis could be a suitable marker for early detection of cancer predisposition. Variants in genes associated with tooth agenesis could serve as prognostic or therapeutic targets in cancer. This review aims to summarize existing knowledge of development and clinical genetics of teeth. Concurrently, the review proposes possible approaches for future research in this area, with particular attention to roles in monitoring, early diagnosis and therapy of tumors associated with defective tooth development.

Citovat

BONCZEK, Ondrej, Premysl KREJCI, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, Igor KISS a Borivoj VOJTESEK. Tooth agenesis: What do we know and is there a connection to cancer? Clinical Genetics. Hoboken: Wiley, 2021, roč. 99, č. 4, s. 493-502. ISSN 0009-9163. Dostupné z: https://dx.doi.org/10.1111/cge.13892.

@article{1758050,
   author = {Bonczek, Ondrej and Krejci, Premysl and Izakovičová Hollá, Lydie and Černochová, Pavlína and Kiss, Igor and Vojtesek, Borivoj},
   article_location = {Hoboken},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/cge.13892},
   keywords = {cancer; genetic variants; hypodontia; odontogenesis; oligodontia; predictive marker; WNT pathway},
   language = {eng},
   issn = {0009-9163},
   journal = {Clinical Genetics},
   title = {Tooth agenesis: What do we know and is there a connection to cancer?},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/cge.13892},
   volume = {99},
   year = {2021}
}

TY  - JOUR
ID  - 1758050
AU  - Bonczek, Ondrej - Krejci, Premysl - Izakovičová Hollá, Lydie - Černochová, Pavlína - Kiss, Igor - Vojtesek, Borivoj
PY  - 2021
TI  - Tooth agenesis: What do we know and is there a connection to cancer?
JF  - Clinical Genetics
VL  - 99
IS  - 4
SP  - 493-502
EP  - 493-502
PB  - Wiley
SN  - 00099163
KW  - cancer
KW  - genetic variants
KW  - hypodontia
KW  - odontogenesis
KW  - oligodontia
KW  - predictive marker
KW  - WNT pathway
UR  - https://onlinelibrary.wiley.com/doi/10.1111/cge.13892
N2  - Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co-expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3, and components and regulators of WNT signaling WNT10B, LRP6, DKK, and KREMEN1 are at the forefront of interest. Due to the interconnectedness of the signaling pathways of carcinogenesis and odontogenesis, tooth agenesis could be a suitable marker for early detection of cancer predisposition. Variants in genes associated with tooth agenesis could serve as prognostic or therapeutic targets in cancer. This review aims to summarize existing knowledge of development and clinical genetics of teeth. Concurrently, the review proposes possible approaches for future research in this area, with particular attention to roles in monitoring, early diagnosis and therapy of tumors associated with defective tooth development.
ER  -

BONCZEK, Ondrej, Premysl KREJCI, Lydie IZAKOVIČOVÁ HOLLÁ, Pavlína ČERNOCHOVÁ, Igor KISS a Borivoj VOJTESEK. Tooth agenesis: What do we know and is there a connection to cancer? \textit{Clinical Genetics}. Hoboken: Wiley, 2021, roč.~99, č.~4, s.~493-502. ISSN~0009-9163. Dostupné z: https://dx.doi.org/10.1111/cge.13892.

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