Secondary Metabolites of Plants as Modulators of Endothelium
Functions

J 2021

Secondary Metabolites of Plants as Modulators of Endothelium Functions

BARTÁKOVÁ, Anna a Marie NOVÁKOVÁ

Základní údaje

Originální název

Secondary Metabolites of Plants as Modulators of Endothelium Functions

Autoři

BARTÁKOVÁ, Anna (203 Česká republika, domácí) a Marie NOVÁKOVÁ (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, MDPI, 2021, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.208

Kód RIV

RIV/00216224:14110/21:00121361

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3390/ijms22052533

UT WoS

000628308000001

Klíčová slova anglicky

endothelium; vasoactive substances; vasodilation; vasoconstriction; nitric oxide

Štítky

14110515, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2022 13:42, Mgr. Tereza Miškechová

Anotace

V originále

According to the World Health Organization, cardiovascular diseases are the main cause of death worldwide. They may be caused by various factors or combinations of factors. Frequently, endothelial dysfunction is involved in either development of the disorder or results from it. On the other hand, the endothelium may be disordered for other reasons, e.g., due to infection, such as COVID-19. The understanding of the role and significance of the endothelium in the body has changed significantly over time-from a simple physical barrier to a complex system encompassing local and systemic regulation of numerous processes in the body. Endothelium disorders may arise from impairment of one or more signaling pathways affecting dilator or constrictor activity, including nitric oxide-cyclic guanosine monophosphate activation, prostacyclin-cyclic adenosine monophosphate activation, phosphodiesterase inhibition, and potassium channel activation or intracellular calcium level inhibition. In this review, plants are summarized as sources of biologically active substances affecting the endothelium. This paper compares individual substances and mechanisms that are known to affect the endothelium, and which subsequently may cause the development of cardiovascular disorders.

Návaznosti

MUNI/A/1246/2020, interní kód MU

Název: Kardiovaskulární systém: od iontového kanálu k celotělovému modelu (Akronym: KAVASYKAMO)

Investor: Masarykova univerzita, Kardiovaskulární systém: od iontového kanálu k celotělovému modelu

MUNI/A/1307/2019, interní kód MU

Název: Kardiovaskulární systém od A do Z (Akronym: KAVASAZ)

Investor: Masarykova univerzita, Kardiovaskulární systém od A do Z, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

BARTÁKOVÁ, Anna a Marie NOVÁKOVÁ. Secondary Metabolites of Plants as Modulators of Endothelium Functions. International Journal of Molecular Sciences. Basel: MDPI, 2021, roč. 22, č. 5, s. 1-27. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms22052533.

@article{1758060,
   author = {Bartáková, Anna and Nováková, Marie},
   article_location = {Basel},
   article_number = {5},
   doi = {http://dx.doi.org/10.3390/ijms22052533},
   keywords = {endothelium; vasoactive substances; vasodilation; vasoconstriction; nitric oxide},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Secondary Metabolites of Plants as Modulators of Endothelium Functions},
   url = {https://www.mdpi.com/1422-0067/22/5/2533},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1758060
AU  - Bartáková, Anna - Nováková, Marie
PY  - 2021
TI  - Secondary Metabolites of Plants as Modulators of Endothelium Functions
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 5
SP  - 1-27
EP  - 1-27
PB  - MDPI
SN  - 14220067
KW  - endothelium
KW  - vasoactive substances
KW  - vasodilation
KW  - vasoconstriction
KW  - nitric oxide
UR  - https://www.mdpi.com/1422-0067/22/5/2533
N2  - According to the World Health Organization, cardiovascular diseases are the main cause of death worldwide. They may be caused by various factors or combinations of factors. Frequently, endothelial dysfunction is involved in either development of the disorder or results from it. On the other hand, the endothelium may be disordered for other reasons, e.g., due to infection, such as COVID-19. The understanding of the role and significance of the endothelium in the body has changed significantly over time-from a simple physical barrier to a complex system encompassing local and systemic regulation of numerous processes in the body. Endothelium disorders may arise from impairment of one or more signaling pathways affecting dilator or constrictor activity, including nitric oxide-cyclic guanosine monophosphate activation, prostacyclin-cyclic adenosine monophosphate activation, phosphodiesterase inhibition, and potassium channel activation or intracellular calcium level inhibition. In this review, plants are summarized as sources of biologically active substances affecting the endothelium. This paper compares individual substances and mechanisms that are known to affect the endothelium, and which subsequently may cause the development of cardiovascular disorders.
ER  -

BARTÁKOVÁ, Anna a Marie NOVÁKOVÁ. Secondary Metabolites of Plants as Modulators of Endothelium Functions. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2021, roč.~22, č.~5, s.~1-27. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms22052533.

Podrobný výpis o publikaci