Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis

TSIVGOULIS, G., A. H. KATSANOS, P. MANDAVA, M. KOHRMANN, L. SOINNE, A. D. BARRETO, V. K. SHARMA, Robert MIKULÍK, K. W. MUIR, T. ROTHLISBERGER, J. C. GROTTA, C. R. LEVI, C. A. MOLINA, M. SAQQUR, D. MAVRIDIS, T. PSALTOPOULOU, M. R. VOSKO, J. B. FIEBACH, E. C. SANDSET, T. A. KENT, A. W. ALEXANDROV, P. D. SCHELLINGER a A. V. ALEXANDROV. Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis. Journal of Hypertension. PHILADELPHIA: William and Wilkins, 2021, roč. 39, č. 2, s. 266-272. ISSN 0263-6352. Dostupné z: https://dx.doi.org/10.1097/HJH.0000000000002628.

Základní údaje

Originální název

Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis

Autoři

TSIVGOULIS, G. (garant), A. H. KATSANOS, P. MANDAVA, M. KOHRMANN, L. SOINNE, A. D. BARRETO, V. K. SHARMA, Robert MIKULÍK (203 Česká republika, domácí), K. W. MUIR, T. ROTHLISBERGER, J. C. GROTTA, C. R. LEVI, C. A. MOLINA, M. SAQQUR, D. MAVRIDIS, T. PSALTOPOULOU, M. R. VOSKO, J. B. FIEBACH, E. C. SANDSET, T. A. KENT, A. W. ALEXANDROV, P. D. SCHELLINGER a A. V. ALEXANDROV

Vydání

Journal of Hypertension, PHILADELPHIA, William and Wilkins, 2021, 0263-6352

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.776

Kód RIV

RIV/00216224:14110/21:00121365

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/HJH.0000000000002628

UT WoS

000612619500011

Klíčová slova anglicky

blood pressure; intracranial hemorrhage; monitoring; outcome; sonothrombolysis; stroke; thrombolysis

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Objective: To investigate the association of blood pressure BP excursions, defined as greater than 185 SBP or greater than 105 DBP, with the probability of intracranial hemorrhage (ICH) and worse functional outcomes in patients with acute ischemic stroke (AIS) treated with tissue plasminogen activator (tPA). Methods: We performed a post hoc analysis of the CLOTBUST-ER trial. Serial BP measurements were conducted using automated cuff recording according to the recommended BP protocol guidelines for tPA administration. The outcomes were prespecified efficacy and safety endpoints of CLOTBUST-ER. Results: The mean number of serial BP recordings per patient was 37. Of the 674 patients, 227 (34%) had at least one BP excursion (>185/105 mmHg) during the first 24 h following tPA-bolus. The majority of BP excursions (46%) occurred within the first 75min from tPA-bolus. Patients with at least one BP excursion in the first 24 h following tPA bolus had significantly lower rates of independent functional outcome at 90 days (31 vs. 40.1%, P = 0.028). The total number of BP excursions was associated with decreased odds of 24-h clinical recovery (OR = 0.88, 95% CI:0.80-0.96), 24-h neurological improvement (OR = 0.87, 95% CI: 0.81-0.94), 7-day functional improvement (common OR = 0.92, 95% CI: 0.87-0.97), 90-day functional improvement (common OR = 0.94, 95% CI: 0.88-0.98) and 90-day independent functional outcome (OR = 0.90, 95% CI: 0.82-0.98) in analyses adjusted for potential confounders. DBP excursions were independently associated with increased odds of any intracranial hemorrhage (OR = 1.26, 95% CI: 1.04-1.53). Conclusion: BP excursions above guideline thresholds during the first 24 h following tPA administration for AIS are common and are independently associated with adverse clinical outcomes.