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@article{1758099,
author = {Munster, Lukas and Fojtů, Michaela and Capakova, Zdenka) and Muchova, Monika and Musilova, Lenka and Vaculovič, Tomáš and Balvan, Jan and Kuritka, Ivo and Masařík, Michal and Vicha, Jan},
article_location = {Oxford},
article_number = {APR 2021},
doi = {http://dx.doi.org/10.1016/j.carbpol.2020.117562},
keywords = {Drug delivery; Cellulose; Dextran; Dextrin; Sodium hyaluronate; Selective oxidation},
language = {eng},
issn = {0144-8617},
journal = {Carbohydrate Polymers},
title = {Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?},
url = {https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub},
volume = {257},
year = {2021}
}
TY - JOUR
ID - 1758099
AU - Munster, Lukas - Fojtů, Michaela - Capakova, Zdenka) - Muchova, Monika - Musilova, Lenka - Vaculovič, Tomáš - Balvan, Jan - Kuritka, Ivo - Masařík, Michal - Vicha, Jan
PY - 2021
TI - Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?
JF - Carbohydrate Polymers
VL - 257
IS - APR 2021
SP - 1-12
EP - 1-12
PB - ELSEVIER SCI LTD
SN - 01448617
KW - Drug delivery
KW - Cellulose
KW - Dextran
KW - Dextrin
KW - Sodium hyaluronate
KW - Selective oxidation
UR - https://www.sciencedirect.com/science/article/pii/S0144861720317355?via%3Dihub
N2 - Study provides an in-depth analysis of the structure-function relationship of polysaccharide anticancer drug carriers and points out benefits and potential drawbacks of differences in polysaccharide glycosidic bonding, branching and drug binding mode of the carriers. Cellulose, dextrin, dextran and hyaluronic acid have been regioselectively oxidized to respective dicarboxylated derivatives, allowing them to directly conjugate cisplatin, while preserving their major structural features intact. The structure of source polysaccharide has crucial impact on conjugation effectiveness, carrier capacity, drug release rates, in vitro cytotoxicity and cellular uptake. For example, while branched structure of dextrin-based carrier partially counter the undesirable initial burst release, it also attenuates the cellular uptake and the cytotoxicity of carried drug. Linear polysaccharides containing beta-(1 -> 4) glycosidic bonds and oxidized at C2 and C3 (cellulose and hyaluronate) have the best overall combination of structural features for improved drug delivery applications including potentiation of the cisplatin efficacy towards malignances.
ER -
MUNSTER, Lukas, Michaela FOJTŮ, Zdenka) CAPAKOVA, Monika MUCHOVA, Lenka MUSILOVA, Tomáš VACULOVIČ, Jan BALVAN, Ivo KURITKA, Michal MASAŘÍK and Jan VICHA. Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure? \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~257, APR 2021, p.~1-12. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2020.117562.
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