Další formáty:
BibTeX
LaTeX
RIS
@article{1758359, author = {Adamczyk, Przemysław and Płonka, Olga and Kruk, Dawid and Jáni, Martin and Błądziński, Piotr and Kalisz, Aneta and Castelein, Stynke and Cechnicki, Andrzej and Wyczesany, Miroslaw}, article_location = {Warsaw}, article_number = {1}, doi = {http://dx.doi.org/10.21307/ane-2021-009}, keywords = {schizophrenia; diffusion tensor imaging; white matter; negative symptoms; psychopathology}, language = {eng}, issn = {0065-1400}, journal = {Acta Neurobiologiae Experimentalis}, title = {On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study}, url = {https://www.exeley.com/exeley/journals/acta_neurobiologiae_experimentalis/81/i_current/pdf/10.21307_ane-2021-009.pdf}, volume = {81}, year = {2021} }
TY - JOUR ID - 1758359 AU - Adamczyk, Przemysław - Płonka, Olga - Kruk, Dawid - Jáni, Martin - Błądziński, Piotr - Kalisz, Aneta - Castelein, Stynke - Cechnicki, Andrzej - Wyczesany, Miroslaw PY - 2021 TI - On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study JF - Acta Neurobiologiae Experimentalis VL - 81 IS - 1 SP - 80-95 EP - 80-95 PB - NENCKI INST EXPERIMENTAL BIOLOGY SN - 00651400 KW - schizophrenia KW - diffusion tensor imaging KW - white matter KW - negative symptoms KW - psychopathology UR - https://www.exeley.com/exeley/journals/acta_neurobiologiae_experimentalis/81/i_current/pdf/10.21307_ane-2021-009.pdf N2 - Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality. ER -
ADAMCZYK, Przemysław, Olga PŁONKA, Dawid KRUK, Martin JÁNI, Piotr BŁĄDZI$\backslash$'NSKI, Aneta KALISZ, Stynke CASTELEIN, Andrzej CECHNICKI a Miroslaw WYCZESANY. On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients - a DTI study. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: NENCKI INST EXPERIMENTAL BIOLOGY, 2021, roč.~81, č.~1, s.~80-95. ISSN~0065-1400. Dostupné z: https://dx.doi.org/10.21307/ane-2021-009.
|