Therapeutic effect of cold atmospheric plasma and its
combination with radiation as a novel approach on inhibiting
cervical cancer cell growth (HeLa cells)

J 2021

Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)

JAMAATI KENARI, Ali, Seyedeh NEDA SIADATI, Zeinab ABEDIAN, Farshad SOHBATZADEH, Mehrangiz AMIRI et. al.

Základní údaje

Originální název

Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)

Autoři

JAMAATI KENARI, Ali (364 Írán, garant, domácí), Seyedeh NEDA SIADATI, Zeinab ABEDIAN, Farshad SOHBATZADEH, Mehrangiz AMIRI, Kourosh EBRAHIMNEJAD GORJI, Hamed BABAPOUR, Ebrahim ZABIHI, Seyedeh MASOUMEH GHOREISHI, Rahele MEHRAEEN a Ali SHABESTANI MONFARED

Vydání

Bioorganic Chemistry, Elsevier, 2021, 0045-2068

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10305 Fluids and plasma physics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.307

Kód RIV

RIV/00216224:14310/21:00121542

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.bioorg.2021.104892

UT WoS

000656969600003

Klíčová slova anglicky

Cervical cancer; Cold plasma therapy; Radiation therapy; Combined therapy

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 6. 2021 10:40, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Cervical cancer is one of the important cancers in women. Research on novel treatment approach can reduce the mortality and burden. Although radiotherapy is a common treatment, its negative side effects have concerned physician. In our study, we studied impact of cold atmospheric pressure plasma on the Hela cancer cells, as an alternative treatment. The effect of three different types of such plasma; dielectric barrier discharge (DBD), plasma jet, and afterglow plasma, on the cancer cells were studied. Moreover, some effective operating parameters such as exposure time, applied voltage, composition of working gas in plasma treatment were investigated on the survival of the afterglow plasma. Finally, treatments by the afterglow plasma, gamma radiation (1 Gy), and combination of both were compared. Analysis showed that DBD and plasma jet (direct exposure) effectively killed the cancer cells, even by a minimum applied voltage. But a fraction of the cells survived after the exposure of indirect diffused afterglow plasma. In the case of this plasma, we realized that higher applied voltage and exposure time led to less cell viability. Fewer fractions of survival cells were detected in the case of argon afterglow plasma comparing to oxygen afterglow. Cold atmospheric plasma and its combination with radiation therapy showed a significant decrease in viability of the cells, comparing to the radiation alone. Our research showed that plasma and its combination with radiation therapy have superiority over radiation therapy.

Citovat

JAMAATI KENARI, Ali, Seyedeh NEDA SIADATI, Zeinab ABEDIAN, Farshad SOHBATZADEH, Mehrangiz AMIRI, Kourosh EBRAHIMNEJAD GORJI, Hamed BABAPOUR, Ebrahim ZABIHI, Seyedeh MASOUMEH GHOREISHI, Rahele MEHRAEEN a Ali SHABESTANI MONFARED. Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells). Bioorganic Chemistry. Elsevier, 2021, roč. 111, June, s. "104892", 8 s. ISSN 0045-2068. Dostupné z: https://dx.doi.org/10.1016/j.bioorg.2021.104892.

@article{1765896,
   author = {Jamaati Kenari, Ali and Neda Siadati, Seyedeh and Abedian, Zeinab and Sohbatzadeh, Farshad and Amiri, Mehrangiz and Ebrahimnejad Gorji, Kourosh and Babapour, Hamed and Zabihi, Ebrahim and Masoumeh Ghoreishi, Seyedeh and Mehraeen, Rahele and Shabestani Monfared, Ali},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.bioorg.2021.104892},
   keywords = {Cervical cancer; Cold plasma therapy; Radiation therapy; Combined therapy},
   language = {eng},
   issn = {0045-2068},
   journal = {Bioorganic Chemistry},
   title = {Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)},
   url = {https://doi.org/10.1016/j.bioorg.2021.104892},
   volume = {111},
   year = {2021}
}

TY  - JOUR
ID  - 1765896
AU  - Jamaati Kenari, Ali - Neda Siadati, Seyedeh - Abedian, Zeinab - Sohbatzadeh, Farshad - Amiri, Mehrangiz - Ebrahimnejad Gorji, Kourosh - Babapour, Hamed - Zabihi, Ebrahim - Masoumeh Ghoreishi, Seyedeh - Mehraeen, Rahele - Shabestani Monfared, Ali
PY  - 2021
TI  - Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells)
JF  - Bioorganic Chemistry
VL  - 111
IS  - June
SP  - "104892"
EP  - "104892"
PB  - Elsevier
SN  - 00452068
KW  - Cervical cancer
KW  - Cold plasma therapy
KW  - Radiation therapy
KW  - Combined therapy
UR  - https://doi.org/10.1016/j.bioorg.2021.104892
N2  - Cervical cancer is one of the important cancers in women. Research on novel treatment approach can reduce the mortality and burden. Although radiotherapy is a common treatment, its negative side effects have concerned physician. In our study, we studied impact of cold atmospheric pressure plasma on the Hela cancer cells, as an alternative treatment. The effect of three different types of such plasma; dielectric barrier discharge (DBD), plasma jet, and afterglow plasma, on the cancer cells were studied. Moreover, some effective operating parameters such as exposure time, applied voltage, composition of working gas in plasma treatment were investigated on the survival of the afterglow plasma. Finally, treatments by the afterglow plasma, gamma radiation (1 Gy), and combination of both were compared. Analysis showed that DBD and plasma jet (direct exposure) effectively killed the cancer cells, even by a minimum applied voltage. But a fraction of the cells survived after the exposure of indirect diffused afterglow plasma. In the case of this plasma, we realized that higher applied voltage and exposure time led to less cell viability. Fewer fractions of survival cells were detected in the case of argon afterglow plasma comparing to oxygen afterglow. Cold atmospheric plasma and its combination with radiation therapy showed a significant decrease in viability of the cells, comparing to the radiation alone. Our research showed that plasma and its combination with radiation therapy have superiority over radiation therapy.
ER  -

JAMAATI KENARI, Ali, Seyedeh NEDA SIADATI, Zeinab ABEDIAN, Farshad SOHBATZADEH, Mehrangiz AMIRI, Kourosh EBRAHIMNEJAD GORJI, Hamed BABAPOUR, Ebrahim ZABIHI, Seyedeh MASOUMEH GHOREISHI, Rahele MEHRAEEN a Ali SHABESTANI MONFARED. Therapeutic effect of cold atmospheric plasma and its combination with radiation as a novel approach on inhibiting cervical cancer cell growth (HeLa cells). \textit{Bioorganic Chemistry}. Elsevier, 2021, roč.~111, June, s.~''104892'', 8 s. ISSN~0045-2068. Dostupné z: https://dx.doi.org/10.1016/j.bioorg.2021.104892.

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