J 2021

Role of SNAREs in Neurodegenerative Diseases

MARGIOTTA, Azzurra

Základní údaje

Originální název

Role of SNAREs in Neurodegenerative Diseases

Autoři

MARGIOTTA, Azzurra (380 Itálie, garant, domácí)

Vydání

Cells, Basel, MDPI, 2021, 2073-4409

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Impakt faktor

Impact factor: 7.666

Kód RIV

RIV/00216224:14110/21:00121544

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000654677300001

Klíčová slova anglicky

SNAREs; neurodegenerative disease; ALS; Parkinson disease; Alzheimer disease; VAMP2; syn1; SNAP-25

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 3. 6. 2021 13:32, Mgr. Tereza Miškechová

Anotace

V originále

Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements. Several neurodegenerative diseases are known such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and many studies on the molecular mechanisms underlying these pathologies have been conducted. Altered functions of some key proteins and the presence of intraneuronal aggregates have been identified as responsible for the development of the diseases. Interestingly, the formation of the SNARE complex has been discovered to be fundamental for vesicle fusion, vesicle recycling and neurotransmitter release. Indeed, inhibition of the formation of the SNARE complex, defects in the SNARE-dependent exocytosis and altered regulation of SNARE-mediated vesicle fusion have been associated with neurodegeneration. In this review, the biological aspects of neurodegenerative diseases and the role of SNARE proteins in relation to the onset of these pathologies are described.