Health Beneficial Properties of Grapevine Seed Extract and Its
Influence on Selected Biochemical Markers in the Blood, Liver
and Kidneys of Rattus norvegicus

J 2021

Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus

SOCHOROVÁ, Lenka, Mojmír BAROŇ, Kateřina DADÁKOVÁ, Tomáš KAŠPAROVSKÝ, Jiří SOCHOR et. al.

Základní údaje

Originální název

Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus

Autoři

SOCHOROVÁ, Lenka (203 Česká republika), Mojmír BAROŇ (203 Česká republika), Kateřina DADÁKOVÁ (203 Česká republika, domácí), Tomáš KAŠPAROVSKÝ (203 Česká republika, garant, domácí) a Jiří SOCHOR (203 Česká republika)

Vydání

Molecules, MDPI, 2021, 1420-3049

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.927

Kód RIV

RIV/00216224:14310/21:00121566

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.3390/molecules26072099

UT WoS

000638729000001

Klíčová slova anglicky

grape seed extract; antioxidants; cadmium; rattus norvegicus; biochemical markers; protective effect

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 5. 2021 18:26, Mgr. Marie Šípková, DiS.

Anotace

V originále

Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.

Citovat

SOCHOROVÁ, Lenka, Mojmír BAROŇ, Kateřina DADÁKOVÁ, Tomáš KAŠPAROVSKÝ a Jiří SOCHOR. Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus. Molecules. MDPI, 2021, roč. 26, č. 7, s. 1-17. ISSN 1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules26072099.

@article{1767716,
   author = {Sochorová, Lenka and Baroň, Mojmír and Dadáková, Kateřina and Kašparovský, Tomáš and Sochor, Jiří},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/molecules26072099},
   keywords = {grape seed extract; antioxidants; cadmium; rattus norvegicus; biochemical markers; protective effect},
   language = {eng},
   issn = {1420-3049},
   journal = {Molecules},
   title = {Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus},
   url = {https://www.mdpi.com/1420-3049/26/7/2099},
   volume = {26},
   year = {2021}
}

TY  - JOUR
ID  - 1767716
AU  - Sochorová, Lenka - Baroň, Mojmír - Dadáková, Kateřina - Kašparovský, Tomáš - Sochor, Jiří
PY  - 2021
TI  - Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus
JF  - Molecules
VL  - 26
IS  - 7
SP  - 1-17
EP  - 1-17
PB  - MDPI
SN  - 14203049
KW  - grape seed extract
KW  - antioxidants
KW  - cadmium
KW  - rattus norvegicus
KW  - biochemical markers
KW  - protective effect
UR  - https://www.mdpi.com/1420-3049/26/7/2099
N2  - Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.
ER  -

SOCHOROVÁ, Lenka, Mojmír BAROŇ, Kateřina DADÁKOVÁ, Tomáš KAŠPAROVSKÝ a Jiří SOCHOR. Health Beneficial Properties of Grapevine Seed Extract and Its Influence on Selected Biochemical Markers in the Blood, Liver and Kidneys of Rattus norvegicus. \textit{Molecules}. MDPI, 2021, roč.~26, č.~7, s.~1-17. ISSN~1420-3049. Dostupné z: https://dx.doi.org/10.3390/molecules26072099.

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