| TYRLÍKOVÁ, Ivana, Zuzana HUMMELOVÁ, Sabina GOLDEMUNDOVÁ, Eva KORIŤÁKOVÁ, Tereza NEČASOVÁ, Mojmir TYRLIK, Milan BRÁZDIL, Jan CHRASTINA, Jan HEMZA a Ivan REKTOR. Memory outcomes of temporal lobe surgery in adults aged over 45 years. Acta Neurologica Scandinavica. Hoboken: WILEY-BLACKWELL, 2021, roč. 144, č. 1, s. 81-91. ISSN 0001-6314. Dostupné z: https://dx.doi.org/10.1111/ane.13427. |
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@article{1769237,
author = {Tyrlíková, Ivana and Hummelová, Zuzana and Goldemundová, Sabina and Koriťáková, Eva and Nečasová, Tereza and Tyrlik, Mojmir and Brázdil, Milan and Chrastina, Jan and Hemza, Jan and Rektor, Ivan},
article_location = {Hoboken},
article_number = {1},
doi = {http://dx.doi.org/10.1111/ane.13427},
keywords = {epilepsy surgery; memory; older patients; temporal lobe epilepsy},
language = {eng},
issn = {0001-6314},
journal = {Acta Neurologica Scandinavica},
title = {Memory outcomes of temporal lobe surgery in adults aged over 45 years},
url = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/ane.13427},
volume = {144},
year = {2021}
}
TY - JOUR
ID - 1769237
AU - Tyrlíková, Ivana - Hummelová, Zuzana - Goldemundová, Sabina - Koriťáková, Eva - Nečasová, Tereza - Tyrlik, Mojmir - Brázdil, Milan - Chrastina, Jan - Hemza, Jan - Rektor, Ivan
PY - 2021
TI - Memory outcomes of temporal lobe surgery in adults aged over 45 years
JF - Acta Neurologica Scandinavica
VL - 144
IS - 1
SP - 81-91
EP - 81-91
PB - WILEY-BLACKWELL
SN - 00016314
KW - epilepsy surgery
KW - memory
KW - older patients
KW - temporal lobe epilepsy
UR - https://onlinelibrary.wiley.com/doi/epdf/10.1111/ane.13427
N2 - Objective It is assumed that temporal lobe resection in older people is associated with worse seizure outcomes and potential postsurgical memory decline. We studied postsurgical memory development and surgical efficacy in patients over 45 years of age compared with younger patients. Methods We studied 88 patients (51 male and 37 female) after temporal lobe surgery, which involved hippocampal resection. The patients were evaluated before surgery and in the first (72 patients) and/or third (57 patients) postsurgical year. The Wechsler Memory Scale III test was performed to evaluate the MQ postsurgical development. Engel's classification was used to evaluate the postsurgical seizure outcome. Results The presurgical MQ (median 88) in >= 45 years age group was significantly lower than in both younger groups (median MQ = 100 for <= 30 years age group, p = 0.002; median MQ = 107 for 31-44 years age group, p = 0.002). Three years after the surgery, the MQ decreased significantly in <= 30 years age group (p = 0.012), while only non-significant MQ decline was observed in both older groups. We found no significant impact of age on the surgical outcome. Conclusion Higher age at the time of surgery does not significantly increase the risk for postsurgical memory decline; however, older patients are more likely to have lowered presurgical MQ. We did not find significant differences in the impact of surgery on seizure outcome among the age groups. Epilepsy surgery appears to be a safe and effective method in the age over 45 years even though an earlier surgery should be preferred.
ER -
TYRLÍKOVÁ, Ivana, Zuzana HUMMELOVÁ, Sabina GOLDEMUNDOVÁ, Eva KORIŤÁKOVÁ, Tereza NEČASOVÁ, Mojmir TYRLIK, Milan BRÁZDIL, Jan CHRASTINA, Jan HEMZA a Ivan REKTOR. Memory outcomes of temporal lobe surgery in adults aged over 45 years. \textit{Acta Neurologica Scandinavica}. Hoboken: WILEY-BLACKWELL, 2021, roč.~144, č.~1, s.~81-91. ISSN~0001-6314. Dostupné z: https://dx.doi.org/10.1111/ane.13427.
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