The neural substrates of diminished humor comprehension in
schizophrenia and its relationship with psychopathology

J 2021

The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology

JÁNI, Martin, Olga PŁONKA, Artur DAREN, Piotr BŁĄDZIŃSKI, Aneta KALISZ et. al.

Základní údaje

Originální název

The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology

Autoři

JÁNI, Martin (703 Slovensko, garant, domácí), Olga PŁONKA, Artur DAREN, Piotr BŁĄDZIŃSKI, Aneta KALISZ, Mirosław WYCZESANY a Przemysław ADAMCZYK

Vydání

Acta Neurobiologiae Experimentalis, Warsaw, NENCKI INST EXPERIMENTAL BIOLOGY, 2021, 0065-1400

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.269

Kód RIV

RIV/00216224:14110/21:00121600

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21307/ane-2021-017

UT WoS

000665479700007

Klíčová slova anglicky

electroencephalography; neuroimaging; psychopathology; schizophrenia; figurative language

Štítky

14110222, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 8. 2021 10:36, Mgr. Tereza Miškechová

Anotace

V originále

Patients with schizophrenia commonly revealed difficulties in understanding humor. Previous research suggested links between impaired humor comprehension, psychopathology symptoms and cognitive deficits. In this study, we investigated the associations between neural substrates of humor processing and psychopathology and cognition in schizophrenia. We assessed 25 schizophrenia outpatients in an functional magnetic resonance imaging (fMRI) procedure and 40 in an electroencephalography (EEG) procedure. A punchline‑based humor comprehension task was used in which outpatients rated stories by their comprehensibility and funniness. The symptom severity and cognition were correlated with activation within the humor processing network using fMRI and effective connectivity using an EEG‑based directed transfer function (DTF) method. More severe positive and disorganization symptoms were associated with impaired humor comprehension and with altered temporo‑parietal effective connectivity during humor processing. More severe excitement and emotional reactivity symptoms were associated with increased activation in the bilateral frontal and temporo‑parietal regions. Moreover, schizophrenia outpatients with better cognitive functioning were more accurate in humor comprehension that was associated with increased fronto‑temporo‑parietal activation and effective connectivity. We found the intensity of humor processing (fMRI) in schizophrenia is related to the level of cognitive abilities and the severity of schizophrenia psychopathology that is also reflected in altered effective connectivity (EEG‑DTF) in the humor processing network.

Citovat

JÁNI, Martin, Olga PŁONKA, Artur DAREN, Piotr BŁĄDZIŃSKI, Aneta KALISZ, Mirosław WYCZESANY a Przemysław ADAMCZYK. The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology. Acta Neurobiologiae Experimentalis. Warsaw: NENCKI INST EXPERIMENTAL BIOLOGY, 2021, roč. 81, č. 2, s. 181-190. ISSN 0065-1400. Dostupné z: https://dx.doi.org/10.21307/ane-2021-017.

@article{1769317,
   author = {Jáni, Martin and Płonka, Olga and Daren, Artur and Błądziński, Piotr and Kalisz, Aneta and Wyczesany, Mirosław and Adamczyk, Przemysław},
   article_location = {Warsaw},
   article_number = {2},
   doi = {http://dx.doi.org/10.21307/ane-2021-017},
   keywords = {electroencephalography; neuroimaging; psychopathology; schizophrenia; figurative language},
   language = {eng},
   issn = {0065-1400},
   journal = {Acta Neurobiologiae Experimentalis},
   title = {The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology},
   url = {https://ane.pl/online-first?vol=81&no=2&id=SkjPJEpzeNHBMvnc},
   volume = {81},
   year = {2021}
}

TY  - JOUR
ID  - 1769317
AU  - Jáni, Martin - Płonka, Olga - Daren, Artur - Błądziński, Piotr - Kalisz, Aneta - Wyczesany, Mirosław - Adamczyk, Przemysław
PY  - 2021
TI  - The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology
JF  - Acta Neurobiologiae Experimentalis
VL  - 81
IS  - 2
SP  - 181-190
EP  - 181-190
PB  - NENCKI INST EXPERIMENTAL BIOLOGY
SN  - 00651400
KW  - electroencephalography
KW  - neuroimaging
KW  - psychopathology
KW  - schizophrenia
KW  - figurative language
UR  - https://ane.pl/online-first?vol=81&no=2&id=SkjPJEpzeNHBMvnc
N2  - Patients with schizophrenia commonly revealed difficulties in understanding humor. Previous research suggested links between impaired humor comprehension, psychopathology symptoms and cognitive deficits. In this study, we investigated the associations between neural substrates of humor processing and psychopathology and cognition in schizophrenia. We assessed 25 schizophrenia outpatients in an functional magnetic resonance imaging (fMRI) procedure and 40 in an electroencephalography (EEG) procedure. A punchline‑based humor comprehension task was used in which outpatients rated stories by their comprehensibility and funniness. The symptom severity and cognition were correlated with activation within the humor processing network using fMRI and effective connectivity using an EEG‑based directed transfer function (DTF) method. More severe positive and disorganization symptoms were associated with impaired humor comprehension and with altered temporo‑parietal effective connectivity during humor processing. More severe excitement and emotional reactivity symptoms were associated with increased activation in the bilateral frontal and temporo‑parietal regions. Moreover, schizophrenia outpatients with better cognitive functioning were more accurate in humor comprehension that was associated with increased fronto‑temporo‑parietal activation and effective connectivity. We found the intensity of humor processing (fMRI) in schizophrenia is related to the level of cognitive abilities and the severity of schizophrenia psychopathology that is also reflected in altered effective connectivity (EEG‑DTF) in the humor processing network.
ER  -

JÁNI, Martin, Olga PŁONKA, Artur DAREN, Piotr BŁĄDZI$\backslash$'NSKI, Aneta KALISZ, Mirosław WYCZESANY a Przemysław ADAMCZYK. The neural substrates of diminished humor comprehension in schizophrenia and its relationship with psychopathology. \textit{Acta Neurobiologiae Experimentalis}. Warsaw: NENCKI INST EXPERIMENTAL BIOLOGY, 2021, roč.~81, č.~2, s.~181-190. ISSN~0065-1400. Dostupné z: https://dx.doi.org/10.21307/ane-2021-017.

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