J 2021

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study Among Healthcare Workers in Turkey

RIAD, Abanoub, Derya SAĞIROĞLU, Batuhan ÜSTÜN, Andrea POKORNÁ, Jitka KLUGAROVÁ et. al.

Basic information

Original name

Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study Among Healthcare Workers in Turkey

Authors

RIAD, Abanoub (818 Egypt, belonging to the institution), Derya SAĞIROĞLU, Batuhan ÜSTÜN, Andrea POKORNÁ (203 Czech Republic, belonging to the institution), Jitka KLUGAROVÁ (203 Czech Republic, belonging to the institution), Sameh ATTIA and Miloslav KLUGAR (203 Czech Republic, belonging to the institution)

Edition

Journal of Clinical Medicine, Basel, MDPI, 2021, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.964

RIV identification code

RIV/00216224:14110/21:00121613

Organization unit

Faculty of Medicine

DOI

UT WoS

000665884700001

Keywords in English

COVID-19; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence

Tags

Tags

International impact, Reviewed
Změněno: 18/10/2021 12:47, Mgr. Tereza Miškechová

Abstract

V originále

Background: COVIC-19 vaccine hesitancy is a serious threat to mass vaccination strategies that need to be accelerated currently for achieving a substantial level of community immunity. Independent (non-sponsored) studies have a great potential to enhance public confidence in vaccines and accelerate their uptake process. Methods: A nationwide cross-sectional study for the side effects (SE) of CoronaVac was carried out in February 2021 among Turkish healthcare workers who got recently vaccinated. The questionnaire inquired about local and systemic SEs that occurred in the short-term, within four weeks, following vaccination. Findings: A total of 780 healthcare workers were included in this study; 62.5% of them experienced at least one SE. Injection site pain (41.5%) was the most common local SE, while fatigue (23.6%), headache (18.7%), muscle pain (11.2%) and joint pain (5.9%) were the common systemic SE. Female healthcare workers (67.9%) were significantly more affected by local and systemic SEs than male colleagues (51.4%). Younger age, previous infection, and compromised health status (chronic illnesses and regular medicines uptake) can be associated with an increased risk of CoronaVac SEs. Interpretation: The independent research shows a higher prevalence of CoronaVac SEs than what is reported by phase 1 – 3 clinical trials. In general, the results of this study confirm the overall safety of CoronaVac and suggest potential risk factors for its SEs. Gender-based differences and SEs distribution among age groups are worth further investigation.

Links

LTC20031, research and development project
Name: Towards an International Network for Evidence-based Research in Clinical Health Research in the Czech Republic
Investor: Ministry of Education, Youth and Sports of the CR, INTER-COST
MUNI/A/1608/2020, interní kód MU
Name: Prohlubování znalostí v oblasti zdravotních rizik a benefitů výživy, prostředí a životního stylu III
Investor: Masaryk University
MUNI/IGA/1543/2020, interní kód MU
Name: Evidence-based Practice of Healthcare Professionals and Students in the Czech Republic (Acronym: Evidence-Based Practice in Czechia)
Investor: Masaryk University