The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower
Occurrence in Patients with Syphilis, Suggesting Its Protective
Effect in Czech and Slovak Individuals

J 2021

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA et. al.

Základní údaje

Originální název

The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals

Autoři

GRILLOVÁ, Linda (203 Česká republika, domácí), Jana MUSILOVA (203 Česká republika), Klára JANEČKOVÁ (203 Česká republika, domácí), Petra POSPÍŠILOVÁ (203 Česká republika, domácí), Ivana KUKLOVA (203 Česká republika), Vladana WOZNICOVÁ (203 Česká republika, domácí), Hana ZAKOUCKA (203 Česká republika) a David ŠMAJS (203 Česká republika, garant, domácí)

Vydání

INFECTION AND IMMUNITY, WASHINGTON, American Society for Microbiology, 2021, 0019-9567

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.609

Kód RIV

RIV/00216224:14110/21:00120100

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1128/IAI.00503-20

UT WoS

000600550700003

Klíčová slova anglicky

Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study

Štítky

14110113, 14110513, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 2. 2022 12:58, Mgr. Tereza Miškechová

Anotace

V originále

Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.

Návaznosti

MUNI/A/1325/2020, interní kód MU

Název: Biomedicínské vědy

Investor: Masarykova univerzita, Biomedicínské vědy

NV17-31333A, projekt VaV

Název: Vývoj nového typovacího systému pro původce syfilis, Treponema pallidum subsp. pallidum, zaměřeného na proteomické rozdíly

Citovat

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA a David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. INFECTION AND IMMUNITY. WASHINGTON: American Society for Microbiology, 2021, roč. 89, č. 1, s. 1-6. ISSN 0019-9567. Dostupné z: https://dx.doi.org/10.1128/IAI.00503-20.

@article{1773198,
   author = {Grillová, Linda and Musilova, Jana and Janečková, Klára and Pospíšilová, Petra and Kuklova, Ivana and Woznicová, Vladana and Zakoucka, Hana and Šmajs, David},
   article_location = {WASHINGTON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1128/IAI.00503-20},
   keywords = {Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study},
   language = {eng},
   issn = {0019-9567},
   journal = {INFECTION AND IMMUNITY},
   title = {The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals},
   url = {https://journals.asm.org/doi/epub/10.1128/IAI.00503-20},
   volume = {89},
   year = {2021}
}

TY  - JOUR
ID  - 1773198
AU  - Grillová, Linda - Musilova, Jana - Janečková, Klára - Pospíšilová, Petra - Kuklova, Ivana - Woznicová, Vladana - Zakoucka, Hana - Šmajs, David
PY  - 2021
TI  - The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals
JF  - INFECTION AND IMMUNITY
VL  - 89
IS  - 1
SP  - 1-6
EP  - 1-6
PB  - American Society for Microbiology
SN  - 00199567
KW  - Toll-like receptor 2
KW  - Treponema pallidum subsp. pallidum
KW  - Arg753Gln polymorphism
KW  - case-control study
UR  - https://journals.asm.org/doi/epub/10.1128/IAI.00503-20
N2  - Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling.
ER  -

GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA a David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. \textit{INFECTION AND IMMUNITY}. WASHINGTON: American Society for Microbiology, 2021, roč.~89, č.~1, s.~1-6. ISSN~0019-9567. Dostupné z: https://dx.doi.org/10.1128/IAI.00503-20.

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