GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA a David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. INFECTION AND IMMUNITY. WASHINGTON: American Society for Microbiology, 2021, roč. 89, č. 1, s. 1-6. ISSN 0019-9567. Dostupné z: https://dx.doi.org/10.1128/IAI.00503-20. |
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@article{1773198, author = {Grillová, Linda and Musilova, Jana and Janečková, Klára and Pospíšilová, Petra and Kuklova, Ivana and Woznicová, Vladana and Zakoucka, Hana and Šmajs, David}, article_location = {WASHINGTON}, article_number = {1}, doi = {http://dx.doi.org/10.1128/IAI.00503-20}, keywords = {Toll-like receptor 2; Treponema pallidum subsp. pallidum; Arg753Gln polymorphism; case-control study}, language = {eng}, issn = {0019-9567}, journal = {INFECTION AND IMMUNITY}, title = {The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals}, url = {https://journals.asm.org/doi/epub/10.1128/IAI.00503-20}, volume = {89}, year = {2021} }
TY - JOUR ID - 1773198 AU - Grillová, Linda - Musilova, Jana - Janečková, Klára - Pospíšilová, Petra - Kuklova, Ivana - Woznicová, Vladana - Zakoucka, Hana - Šmajs, David PY - 2021 TI - The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals JF - INFECTION AND IMMUNITY VL - 89 IS - 1 SP - 1-6 EP - 1-6 PB - American Society for Microbiology SN - 00199567 KW - Toll-like receptor 2 KW - Treponema pallidum subsp. pallidum KW - Arg753Gln polymorphism KW - case-control study UR - https://journals.asm.org/doi/epub/10.1128/IAI.00503-20 N2 - Syphilis is a bacterial infection caused by Treponema pallidum subsp. pallidum. Infection with T. pallidum subsp. pallidum and its dissemination lead to the synthesis of proinflammatory cytokines triggered by the interaction of bacterial lipoproteins with Toll-like receptor 2 (TLR2). TLR2 contains several nonsynonymous single-nucleotide polymorphisms that may impact the activation of its signaling cascade and alter the responsiveness to, or the course of, various infectious diseases, including those caused by pathogenic spirochetes. To investigate whether TLR2 polymorphism may influence susceptibility to syphilis, 221 healthy individuals with no history of syphilis (controls) and 137 patients diagnosed with syphilis (cases) were screened for the presence of the Arg753Gln polymorphism in the TLR2 gene (2258G -> A; rs5743708). The Arg753Gln variant occurs at a significantly lower frequency in syphilis patients (4 of 137 [3%]) than in controls (24 of 221 [10.9%]). These data suggest that TLR2 Arg753Gln may protect from the development of syphilis due to reduced signaling. ER -
GRILLOVÁ, Linda, Jana MUSILOVA, Klára JANEČKOVÁ, Petra POSPÍŠILOVÁ, Ivana KUKLOVA, Vladana WOZNICOVÁ, Hana ZAKOUCKA a David ŠMAJS. The Arg753Gln Polymorphism of Toll-Like Receptor 2 Has a Lower Occurrence in Patients with Syphilis, Suggesting Its Protective Effect in Czech and Slovak Individuals. \textit{INFECTION AND IMMUNITY}. WASHINGTON: American Society for Microbiology, 2021, roč.~89, č.~1, s.~1-6. ISSN~0019-9567. Dostupné z: https://dx.doi.org/10.1128/IAI.00503-20.
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